Incorporating Blood Flow in Nerve Injury and Regeneration Assessment
Peripheral nerve injury is a significant public health challenge, with limited treatment options and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy, the vascular network of nerves impact regeneration, including perfusion for metabolic demands, appropriate si...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.862478/full |
| _version_ | 1811299980273516544 |
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| author | Stewart Yeoh Wesley S. Warner Samer S. Merchant Edward W. Hsu Denes v. Agoston Mark A. Mahan |
| author_facet | Stewart Yeoh Wesley S. Warner Samer S. Merchant Edward W. Hsu Denes v. Agoston Mark A. Mahan |
| author_sort | Stewart Yeoh |
| collection | DOAJ |
| description | Peripheral nerve injury is a significant public health challenge, with limited treatment options and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy, the vascular network of nerves impact regeneration, including perfusion for metabolic demands, appropriate signaling and growth factors, and structural scaffolding for Schwann cell and axonal migration. However, the established nerve injury classification paradigm proposed by Sydney Sunderland in 1951 is based solely on hierarchical disruption to gross anatomical nerve structures and lacks further information regarding the state of cellular, metabolic, or inflammatory processes that are critical in determining regenerative outcomes. This review covers the anatomical structure of nerve-associated vasculature, and describes the biological processes that makes these vessels critical to successful end-organ reinnervation after severe nerve injuries. We then propose a theoretical framework that incorporates measurements of blood vessel perfusion and inflammation to unify perspectives on all mechanisms of nerve injury. |
| first_indexed | 2024-04-13T06:43:37Z |
| format | Article |
| id | doaj.art-2cd604d848254c06829033bbdafd3998 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-13T06:43:37Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-2cd604d848254c06829033bbdafd39982022-12-22T02:57:39ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-04-01910.3389/fsurg.2022.862478862478Incorporating Blood Flow in Nerve Injury and Regeneration AssessmentStewart Yeoh0Wesley S. Warner1Samer S. Merchant2Edward W. Hsu3Denes v. Agoston4Mark A. Mahan5Department of Neurosurgery, University of Utah, Salt Lake City, Utah, United StatesDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah, United StatesDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United StatesDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, United StatesDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United StatesDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah, United StatesPeripheral nerve injury is a significant public health challenge, with limited treatment options and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy, the vascular network of nerves impact regeneration, including perfusion for metabolic demands, appropriate signaling and growth factors, and structural scaffolding for Schwann cell and axonal migration. However, the established nerve injury classification paradigm proposed by Sydney Sunderland in 1951 is based solely on hierarchical disruption to gross anatomical nerve structures and lacks further information regarding the state of cellular, metabolic, or inflammatory processes that are critical in determining regenerative outcomes. This review covers the anatomical structure of nerve-associated vasculature, and describes the biological processes that makes these vessels critical to successful end-organ reinnervation after severe nerve injuries. We then propose a theoretical framework that incorporates measurements of blood vessel perfusion and inflammation to unify perspectives on all mechanisms of nerve injury.https://www.frontiersin.org/articles/10.3389/fsurg.2022.862478/fullperfusionnerve injuryregenerationperipheral nerveblood vesselSunderland injury classification |
| spellingShingle | Stewart Yeoh Wesley S. Warner Samer S. Merchant Edward W. Hsu Denes v. Agoston Mark A. Mahan Incorporating Blood Flow in Nerve Injury and Regeneration Assessment Frontiers in Surgery perfusion nerve injury regeneration peripheral nerve blood vessel Sunderland injury classification |
| title | Incorporating Blood Flow in Nerve Injury and Regeneration Assessment |
| title_full | Incorporating Blood Flow in Nerve Injury and Regeneration Assessment |
| title_fullStr | Incorporating Blood Flow in Nerve Injury and Regeneration Assessment |
| title_full_unstemmed | Incorporating Blood Flow in Nerve Injury and Regeneration Assessment |
| title_short | Incorporating Blood Flow in Nerve Injury and Regeneration Assessment |
| title_sort | incorporating blood flow in nerve injury and regeneration assessment |
| topic | perfusion nerve injury regeneration peripheral nerve blood vessel Sunderland injury classification |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.862478/full |
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