Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?
Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-infection. Due to the extensive antibiotic and pan-r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1049917/full |
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| author | Yue Hu Yue Hu Xianqin Zhang Shanshan Deng Shanshan Deng Changwu Yue Xu Jia Xu Jia Yuhong Lyu |
| author_facet | Yue Hu Yue Hu Xianqin Zhang Shanshan Deng Shanshan Deng Changwu Yue Xu Jia Xu Jia Yuhong Lyu |
| author_sort | Yue Hu |
| collection | DOAJ |
| description | Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-infection. Due to the extensive antibiotic and pan-resistance, A. baumannii infection is facing fewer treatment options in the clinic. Therefore, the prevention and treatment of A. baumannii infection have become a tricky global problem. The requirement for research and development of the new strategy is urgent. Now, non-antibiotic treatment strategies are urgently needed. This review describes the research on A. baumannii vaccines and antibacterial adjuvants, discusses the advantages and disadvantages of different candidate vaccines tested in vitro and in vivo, especially subunit protein vaccines, and shows the antibacterial efficacy of adjuvant drugs in monotherapy. |
| first_indexed | 2024-04-10T20:27:12Z |
| format | Article |
| id | doaj.art-2cd64d38c22643dd9f5f5e238e722be5 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-10T20:27:12Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-2cd64d38c22643dd9f5f5e238e722be52023-01-25T08:15:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-01-011410.3389/fmicb.2023.10499171049917Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?Yue Hu0Yue Hu1Xianqin Zhang2Shanshan Deng3Shanshan Deng4Changwu Yue5Xu Jia6Xu Jia7Yuhong Lyu8Yan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, Yan'An, ChinaNon-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, ChinaSchool of Basic Medical Sciences, Chengdu Medical College, Chengdu, ChinaNon-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, ChinaSchool of Basic Medical Sciences, Chengdu Medical College, Chengdu, ChinaYan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, Yan'An, ChinaNon-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, ChinaSchool of Basic Medical Sciences, Chengdu Medical College, Chengdu, ChinaYan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, Yan'An, ChinaAcinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-infection. Due to the extensive antibiotic and pan-resistance, A. baumannii infection is facing fewer treatment options in the clinic. Therefore, the prevention and treatment of A. baumannii infection have become a tricky global problem. The requirement for research and development of the new strategy is urgent. Now, non-antibiotic treatment strategies are urgently needed. This review describes the research on A. baumannii vaccines and antibacterial adjuvants, discusses the advantages and disadvantages of different candidate vaccines tested in vitro and in vivo, especially subunit protein vaccines, and shows the antibacterial efficacy of adjuvant drugs in monotherapy.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1049917/fullAcinetobacter baumanniiwhole-cell vaccineOMVDNA vaccinerecombinant protein subunit vaccineadjuvant drugs |
| spellingShingle | Yue Hu Yue Hu Xianqin Zhang Shanshan Deng Shanshan Deng Changwu Yue Xu Jia Xu Jia Yuhong Lyu Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? Frontiers in Microbiology Acinetobacter baumannii whole-cell vaccine OMV DNA vaccine recombinant protein subunit vaccine adjuvant drugs |
| title | Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? |
| title_full | Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? |
| title_fullStr | Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? |
| title_full_unstemmed | Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? |
| title_short | Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies? |
| title_sort | non antibiotic prevention and treatment against acinetobacter baumannii infection are vaccines and adjuvants effective strategies |
| topic | Acinetobacter baumannii whole-cell vaccine OMV DNA vaccine recombinant protein subunit vaccine adjuvant drugs |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1049917/full |
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