USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Abstract Background The focus of studies on high-density lipoproteins (HDL) has shifted from HDL-cholesterol (HDL-C) to HDL function. We recently demonstrated that low USF1 expression in mice and humans associates with high plasma HDL-C and low triglyceride levels, as well as protection against obes...

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Bibliographic Details
Main Authors: Maija Ruuth, Jarkko Soronen, Essi Kaiharju, Krista Merikanto, Julia Perttilä, Jari Metso, Miriam Lee-Rueckert, Marja-Riitta Taskinen, Petri T. Kovanen, Katariina Öörni, Vesa M. Olkkonen, Matti S. Jauhiainen, Pirkka-Pekka Laurila
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Lipids in Health and Disease
Subjects:
USF1
High density lipoproteins
Cholesterol efflux
Cholesterol accumulation
Macrophage
Hepatocyte
Online Access:http://link.springer.com/article/10.1186/s12944-018-0930-2

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