Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors
The results of treatment in 17 patients with morphologically confirmed resectable primary or recurrent retroperitoneal tumor using intraoperative photodynamic therapy with photogem (5 patients), radaсhlorin (7 patients) and photodithazine (5 patients). The drugs were administered intravenously in fo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2013-06-01
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| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/11 |
| _version_ | 1797883696235151360 |
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| author | L. А. Vashakmadze Е. V. Filonenko V. V. Cheremisov V. М. Khomyakov |
| author_facet | L. А. Vashakmadze Е. V. Filonenko V. V. Cheremisov V. М. Khomyakov |
| author_sort | L. А. Vashakmadze |
| collection | DOAJ |
| description | The results of treatment in 17 patients with morphologically confirmed resectable primary or recurrent retroperitoneal tumor using intraoperative photodynamic therapy with photogem (5 patients), radaсhlorin (7 patients) and photodithazine (5 patients). The drugs were administered intravenously in following regimen: photogem 48 h before surgery in dose 2.5–3.0 mg/kg, radaсhlorin and photodithazine – 0.7 and 0.7–1.0 mg/kg, respectively, 2–3 h before resection. Irradiation was performed to tumor bed after complete radical removal from one or several positions depending on tumor localization. The light dose accounted for 30 J/cm2, duration of treatment session depended on area of irradiation. Two patients with recurrent tumor had two reoperations with session of photodynamic therapy. One patient had repeated recurrence requiring third surgery with photodynamic therapy. Thus, 17 patients underwent 25 sessions of intraoperative photodynamic therapy. There were no intraoperative complications. One patient had an early post-operative complication in the form of pancreonecrosis which could be associated with extended resection. The recurrence rate was 17.6%. The results showed safety of the method and affinity of utilized photosensitizers to retroperitoneal tumors of different histological types (sarcoma, gastrointestinal stromal tumor and others). |
| first_indexed | 2024-04-10T03:55:49Z |
| format | Article |
| id | doaj.art-2cd712925f864e71a43241e06e09fb65 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:49Z |
| publishDate | 2013-06-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-2cd712925f864e71a43241e06e09fb652023-03-13T07:12:29ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322013-06-012281211Intraoperative photodynamic therapy for nonorgan retroperitoneal tumorsL. А. Vashakmadze0Е. V. Filonenko1V. V. Cheremisov2V. М. Khomyakov3Национальный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, Россия; Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияThe results of treatment in 17 patients with morphologically confirmed resectable primary or recurrent retroperitoneal tumor using intraoperative photodynamic therapy with photogem (5 patients), radaсhlorin (7 patients) and photodithazine (5 patients). The drugs were administered intravenously in following regimen: photogem 48 h before surgery in dose 2.5–3.0 mg/kg, radaсhlorin and photodithazine – 0.7 and 0.7–1.0 mg/kg, respectively, 2–3 h before resection. Irradiation was performed to tumor bed after complete radical removal from one or several positions depending on tumor localization. The light dose accounted for 30 J/cm2, duration of treatment session depended on area of irradiation. Two patients with recurrent tumor had two reoperations with session of photodynamic therapy. One patient had repeated recurrence requiring third surgery with photodynamic therapy. Thus, 17 patients underwent 25 sessions of intraoperative photodynamic therapy. There were no intraoperative complications. One patient had an early post-operative complication in the form of pancreonecrosis which could be associated with extended resection. The recurrence rate was 17.6%. The results showed safety of the method and affinity of utilized photosensitizers to retroperitoneal tumors of different histological types (sarcoma, gastrointestinal stromal tumor and others).https://www.pdt-journal.com/jour/article/view/11интраоперационная фотодинамическая терапиязабрюшинные опухолифотогемфотодитазинрадахлорин |
| spellingShingle | L. А. Vashakmadze Е. V. Filonenko V. V. Cheremisov V. М. Khomyakov Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors Biomedical Photonics интраоперационная фотодинамическая терапия забрюшинные опухоли фотогем фотодитазин радахлорин |
| title | Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| title_full | Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| title_fullStr | Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| title_full_unstemmed | Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| title_short | Intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| title_sort | intraoperative photodynamic therapy for nonorgan retroperitoneal tumors |
| topic | интраоперационная фотодинамическая терапия забрюшинные опухоли фотогем фотодитазин радахлорин |
| url | https://www.pdt-journal.com/jour/article/view/11 |
| work_keys_str_mv | AT lavashakmadze intraoperativephotodynamictherapyfornonorganretroperitonealtumors AT evfilonenko intraoperativephotodynamictherapyfornonorganretroperitonealtumors AT vvcheremisov intraoperativephotodynamictherapyfornonorganretroperitonealtumors AT vmkhomyakov intraoperativephotodynamictherapyfornonorganretroperitonealtumors |