Detection of Microsatellite Instability in Colonoscopic Biopsies and Postal Urine Samples from Lynch Syndrome Cancer Patients Using a Multiplex PCR Assay

Detection of Microsatellite Instability in Colonoscopic Biopsies and Postal Urine Samples from Lynch Syndrome Cancer Patients Using a Multiplex PCR Assay

Identification of mismatch repair (MMR)-deficient colorectal cancers (CRCs) is recommended for Lynch syndrome (LS) screening, and supports targeting of immune checkpoint inhibitors. Microsatellite instability (MSI) analysis is commonly used to test for MMR deficiency. Testing biopsies prior to tumou...

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Bibliographic Details
Main Authors: Rachel Phelps, Richard Gallon, Christine Hayes, Eli Glover, Philip Gibson, Ibrahim Edidi, Tom Lee, Sarah Mills, Adam Shaw, Rakesh Heer, Angela Ralte, Ciaron McAnulty, Mauro Santibanez-Koref, John Burn, Michael S. Jackson
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
Lynch syndrome
mismatch-repair deficiency
microsatellite instability
tumour biopsy
liquid biopsy
Online Access:https://www.mdpi.com/2072-6694/14/15/3838

Internet

https://www.mdpi.com/2072-6694/14/15/3838

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