Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid
OBJECTIVE: Leptin is considered to be a signal factor that regulates body weight and energy expenditure, and there is a strong correlation between serum leptin concentrations, body mass index, and body fat mass in humans. Our aim in this study was to evaluate the role of leptin in valproic acid (VPA...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2011-03-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-43660&look4= |
| _version_ | 1797917218112012288 |
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| author | İrem Fatma Uludağ Ufuk Şener Yaşar Zorlu Mehmet Hicri Köseoğlu Tuğba Kantaroğlu Aydın |
| author_facet | İrem Fatma Uludağ Ufuk Şener Yaşar Zorlu Mehmet Hicri Köseoğlu Tuğba Kantaroğlu Aydın |
| author_sort | İrem Fatma Uludağ |
| collection | DOAJ |
| description | OBJECTIVE: Leptin is considered to be a signal factor that regulates body weight and energy expenditure, and there is a strong correlation between serum leptin concentrations, body mass index, and body fat mass in humans. Our aim in this study was to evaluate the role of leptin in valproic acid (VPA) and topiramate (TPM) related weight changes in epileptic patients.
METHODS: Body mass index is calculated and serum leptin and insulin levels are measured in 56 patients with epilepsy (40 patients taking VPA and 16 patients taking VPA and TPM) and in 40 healty control subjects.
RESULTS: Obesity was seen in 21 patients (52.5%) in VPA treated group, in 15 patients (37.5%) in the control group and in only one male (6.3%) in VPA and TPM treated group. Body mass index was lower in the group treated with VPA and TPM (p<0.001). Serum leptin concentrations were correlated with the body mass index (r=0.49, p<0.001) and were significantly higher in obese subjects (p<0.001) and in women (p<0.001). Serum leptin levels were significantly lower in patients treated with VPA and TPM (p<0.05).
CONCLUSION: High levels of serum leptin in patients taking VPA and significantly low levels of serum leptin in patients taking VPA and TPM in our study are in agreement with the hypotheses that weight changes induced with VPA and TPM are related with the alterations in serum leptin levels. |
| first_indexed | 2024-04-10T13:10:10Z |
| format | Article |
| id | doaj.art-2cd9be288dac4fd9bc26ed77da645611 |
| institution | Directory Open Access Journal |
| issn | 1301-062X |
| language | English |
| last_indexed | 2024-04-10T13:10:10Z |
| publishDate | 2011-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-2cd9be288dac4fd9bc26ed77da6456112023-02-15T16:12:40ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X2011-03-011711731Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acidİrem Fatma Uludağ0Ufuk Şener1Yaşar Zorlu2Mehmet Hicri Köseoğlu3Tuğba Kantaroğlu Aydın4Izmir Tepecik Educational And Research Hospital, Neurology Clinic, TurkeyIzmir Tepecik Educational And Research Hospital, Neurology Clinic, TurkeyIzmir Tepecik Educational And Research Hospital, Neurology Clinic, TurkeyIzmir Ataturk Educational And Research Hospital, 2nd Biochemistry And Clinic Biochemistry Laboratory, TurkeyIzmir Ataturk Educational And Research Hospital, 2nd Biochemistry And Clinic Biochemistry Laboratory, TurkeyOBJECTIVE: Leptin is considered to be a signal factor that regulates body weight and energy expenditure, and there is a strong correlation between serum leptin concentrations, body mass index, and body fat mass in humans. Our aim in this study was to evaluate the role of leptin in valproic acid (VPA) and topiramate (TPM) related weight changes in epileptic patients. METHODS: Body mass index is calculated and serum leptin and insulin levels are measured in 56 patients with epilepsy (40 patients taking VPA and 16 patients taking VPA and TPM) and in 40 healty control subjects. RESULTS: Obesity was seen in 21 patients (52.5%) in VPA treated group, in 15 patients (37.5%) in the control group and in only one male (6.3%) in VPA and TPM treated group. Body mass index was lower in the group treated with VPA and TPM (p<0.001). Serum leptin concentrations were correlated with the body mass index (r=0.49, p<0.001) and were significantly higher in obese subjects (p<0.001) and in women (p<0.001). Serum leptin levels were significantly lower in patients treated with VPA and TPM (p<0.05). CONCLUSION: High levels of serum leptin in patients taking VPA and significantly low levels of serum leptin in patients taking VPA and TPM in our study are in agreement with the hypotheses that weight changes induced with VPA and TPM are related with the alterations in serum leptin levels.http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-43660&look4=Leptinvalproic acidtopiramateobesityepilepsy |
| spellingShingle | İrem Fatma Uludağ Ufuk Şener Yaşar Zorlu Mehmet Hicri Köseoğlu Tuğba Kantaroğlu Aydın Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid Türk Nöroloji Dergisi Leptin valproic acid topiramate obesity epilepsy |
| title | Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid |
| title_full | Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid |
| title_fullStr | Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid |
| title_full_unstemmed | Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid |
| title_short | Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid |
| title_sort | serum leptin levels in epileptic patients treated with topiramate and valproic acid |
| topic | Leptin valproic acid topiramate obesity epilepsy |
| url | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-43660&look4= |
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