Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet
Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2009-12-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/535 |
| _version_ | 1818913665829568512 |
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| author | Eka Deddy Irawan Achmad Fudholi |
| author_facet | Eka Deddy Irawan Achmad Fudholi |
| author_sort | Eka Deddy Irawan |
| collection | DOAJ |
| description | Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg). |
| first_indexed | 2024-12-19T23:34:06Z |
| format | Article |
| id | doaj.art-2cda01f265324070915c1de412100636 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-19T23:34:06Z |
| publishDate | 2009-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-2cda01f265324070915c1de4121006362022-12-21T20:01:40ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862009-12-0120423123810.14499/indonesianjpharm0iss0pp231-238Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tabletEka Deddy Irawan0Achmad Fudholi1Fakultas Farmasi Universitas Jember, Jember Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta Captopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captopril is only 6–8 h. Captopril is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captopril mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimum formula of mucoadhesive tablet for captopril using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were perfomed to establish composition of chitosan, sodium CMC and Mg stearat. Such composition could produce mucoadhesive strength with a zero order release kinetics. A 23 factorial design has been applied to systematically optimize the formula. The amounts of chitosan (XA), sodium CMC (XB), and Mg stearat (XC) were selected as independent variables. Mucoadhesive strength and dissolution efficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70 %) chitosan at low to middle level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low to middle level (4-6 mg).http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/535mucoadhesivefactorial designDE480chitosanCMC NaMg stearatcontour plot |
| spellingShingle | Eka Deddy Irawan Achmad Fudholi Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet Indonesian Journal of Pharmacy mucoadhesive factorial design DE480 chitosan CMC Na Mg stearat contour plot |
| title | Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| title_full | Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| title_fullStr | Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| title_full_unstemmed | Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| title_short | Optimization of chitosan, sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| title_sort | optimization of chitosan sodium carboxy methyl celulose and magnesium stearat as mucoadhesive system in captopril tablet |
| topic | mucoadhesive factorial design DE480 chitosan CMC Na Mg stearat contour plot |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/535 |
| work_keys_str_mv | AT ekadeddyirawan optimizationofchitosansodiumcarboxymethylceluloseandmagnesiumstearatasmucoadhesivesystemincaptopriltablet AT achmadfudholi optimizationofchitosansodiumcarboxymethylceluloseandmagnesiumstearatasmucoadhesivesystemincaptopriltablet |