Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System

Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs can be identified by embryonic stem cell ma...

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Bibliographic Details
Main Authors: David CH Tan, Imogen M Roth, Agadha C Wickremesekera, Paul F Davis, Andrew H Kaye, Theo Mantamadiotis, Stanley S Stylli, Swee T Tan
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
glioblastoma
renin-angiotensin system
cancer stem cells
drug repurposing
Online Access:https://www.mdpi.com/2073-4409/8/11/1364

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