Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis
<h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 pat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530351/?tool=EBI |
| _version_ | 1830440685522649088 |
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| author | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu |
| author_facet | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu |
| author_sort | Ashutosh Nath Aggarwal |
| collection | DOAJ |
| description | <h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. <h4>Methods</h4> We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. <h4>Results</h4> We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. <h4>Conclusion</h4> Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality. |
| first_indexed | 2024-12-21T05:08:26Z |
| format | Article |
| id | doaj.art-2cdab524eb994168a35413af312820fb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T05:08:26Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2cdab524eb994168a35413af312820fb2022-12-21T19:15:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011610Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysisAshutosh Nath AggarwalRitesh AgarwalSahajal DhooriaKuruswamy Thurai PrasadInderpaul Singh SehgalValliappan Muthu<h4>Objective</h4> The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. <h4>Methods</h4> We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. <h4>Results</h4> We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. <h4>Conclusion</h4> Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530351/?tool=EBI |
| spellingShingle | Ashutosh Nath Aggarwal Ritesh Agarwal Sahajal Dhooria Kuruswamy Thurai Prasad Inderpaul Singh Sehgal Valliappan Muthu Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis PLoS ONE |
| title | Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis |
| title_full | Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis |
| title_fullStr | Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis |
| title_full_unstemmed | Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis |
| title_short | Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis |
| title_sort | active pulmonary tuberculosis and coronavirus disease 2019 a systematic review and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530351/?tool=EBI |
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