Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases
Abstract To analyze the performance of ultra-wide-field (UWF) fundus photography compared with ophthalmoscopy in identifying and classifying retinal diseases. Patients examined for presumed major retinal disorders were consecutively enrolled. Each patient underwent indirect ophthalmoscopic evaluatio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23170-4 |
| _version_ | 1828098584645468160 |
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| author | E. Midena G. Marchione S. Di Giorgio G. Rotondi E. Longhin L. Frizziero E. Pilotto R. Parrozzani G. Midena |
| author_facet | E. Midena G. Marchione S. Di Giorgio G. Rotondi E. Longhin L. Frizziero E. Pilotto R. Parrozzani G. Midena |
| author_sort | E. Midena |
| collection | DOAJ |
| description | Abstract To analyze the performance of ultra-wide-field (UWF) fundus photography compared with ophthalmoscopy in identifying and classifying retinal diseases. Patients examined for presumed major retinal disorders were consecutively enrolled. Each patient underwent indirect ophthalmoscopic evaluation, with scleral depression and/or fundus biomicroscopy, when clinically indicated, and mydriatic UWF fundus imaging by means of CLARUS 500™ fundus camera. Each eye was classified by a clinical grader and two image graders in the following groups: normal retina, diabetic retinopathy, vascular abnormalities, macular degenerations and dystrophies, retinal and choroidal tumors, peripheral degenerative lesions and retinal detachment and myopic alterations. 7024 eyes of new patients were included. The inter-grader agreement for images classification was perfect (kappa = 0.998, 95% Confidence Interval (95%CI) = 0.997–0.999), as the two methods concordance for retinal diseases diagnosis (kappa = 0.997, 95%CI = 0.996–0.999) without statistically significant difference. UWF fundus imaging might be an alternative to ophthalmoscopy, since it allows to accurately classify major retinal diseases, widening the range of disorders possibly diagnosed with teleophthalmology. Although the clinician should be aware of the possibility that a minority of the most peripheral lesions may be not entirely visualized, it might be considered a first line diagnostic modality, in the context of a full ophthalmological examination. |
| first_indexed | 2024-04-11T08:03:24Z |
| format | Article |
| id | doaj.art-2cdc9e3ac045435cabea6587bb23c320 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T08:03:24Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2cdc9e3ac045435cabea6587bb23c3202022-12-22T04:35:37ZengNature PortfolioScientific Reports2045-23222022-11-011211710.1038/s41598-022-23170-4Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseasesE. Midena0G. Marchione1S. Di Giorgio2G. Rotondi3E. Longhin4L. Frizziero5E. Pilotto6R. Parrozzani7G. Midena8Department of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaDepartment of Ophthalmology, University of PadovaIRCCS–Fondazione BiettiAbstract To analyze the performance of ultra-wide-field (UWF) fundus photography compared with ophthalmoscopy in identifying and classifying retinal diseases. Patients examined for presumed major retinal disorders were consecutively enrolled. Each patient underwent indirect ophthalmoscopic evaluation, with scleral depression and/or fundus biomicroscopy, when clinically indicated, and mydriatic UWF fundus imaging by means of CLARUS 500™ fundus camera. Each eye was classified by a clinical grader and two image graders in the following groups: normal retina, diabetic retinopathy, vascular abnormalities, macular degenerations and dystrophies, retinal and choroidal tumors, peripheral degenerative lesions and retinal detachment and myopic alterations. 7024 eyes of new patients were included. The inter-grader agreement for images classification was perfect (kappa = 0.998, 95% Confidence Interval (95%CI) = 0.997–0.999), as the two methods concordance for retinal diseases diagnosis (kappa = 0.997, 95%CI = 0.996–0.999) without statistically significant difference. UWF fundus imaging might be an alternative to ophthalmoscopy, since it allows to accurately classify major retinal diseases, widening the range of disorders possibly diagnosed with teleophthalmology. Although the clinician should be aware of the possibility that a minority of the most peripheral lesions may be not entirely visualized, it might be considered a first line diagnostic modality, in the context of a full ophthalmological examination.https://doi.org/10.1038/s41598-022-23170-4 |
| spellingShingle | E. Midena G. Marchione S. Di Giorgio G. Rotondi E. Longhin L. Frizziero E. Pilotto R. Parrozzani G. Midena Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases Scientific Reports |
| title | Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| title_full | Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| title_fullStr | Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| title_full_unstemmed | Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| title_short | Ultra-wide-field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| title_sort | ultra wide field fundus photography compared to ophthalmoscopy in diagnosing and classifying major retinal diseases |
| url | https://doi.org/10.1038/s41598-022-23170-4 |
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