Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan
Abstract Background The Kazakhs are one of the biggest Turkic-speaking ethnic groups, controlling vast swaths of land from the Altai to the Caspian Sea. In terms of area, Kazakhstan is ranked ninth in the world. Northern, Eastern, and Western Kazakhstan have already been studied in relation to genet...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-023-09753-z |
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| author | Yeldar Ashirbekov Madina Seidualy Arman Abaildayev Albina Maxutova Aigul Zhunussova Ainur Akilzhanova Kamalidin Sharipov Zhaxylyk Sabitov Maxat Zhabagin |
| author_facet | Yeldar Ashirbekov Madina Seidualy Arman Abaildayev Albina Maxutova Aigul Zhunussova Ainur Akilzhanova Kamalidin Sharipov Zhaxylyk Sabitov Maxat Zhabagin |
| author_sort | Yeldar Ashirbekov |
| collection | DOAJ |
| description | Abstract Background The Kazakhs are one of the biggest Turkic-speaking ethnic groups, controlling vast swaths of land from the Altai to the Caspian Sea. In terms of area, Kazakhstan is ranked ninth in the world. Northern, Eastern, and Western Kazakhstan have already been studied in relation to genetic polymorphism 27 Y-STR. However, current information on the genetic polymorphism of the Y-chromosome of Southern Kazakhstan is limited only by 17 Y-STR and no geographical study of other regions has been studied at this variation. Results The Kazakhstan Y-chromosome Haplotype Reference Database was expanded with 468 Kazakh males from the Zhambyl and Turkestan regions of South Kazakhstan by having their 27 Y-STR loci and 23 Y-SNP markers analyzed. Discrimination capacity (DC = 91.23%), haplotype match probability (HPM = 0.0029) and haplotype diversity (HD = 0.9992) are defined. Most of this Y-chromosome variability is attributed to haplogroups C2a1a1b1-F1756 (2.1%), C2a1a2-M48 (7.3%), C2a1a3-F1918 (33.3%) and C2b1a1a1a-M407 (6%). Median-joining network analysis was applied to understand the relationship between the haplotypes of the three regions. In three genetic layer can be described the position of the populations of the Southern region of Kazakhstan—the geographic Kazakh populations of Kazakhstan, the Kazakh tribal groups, and the people of bordering Asia. Conclusion The Kazakhstan Y-chromosome Haplotype Reference Database was formed for 27 Y-STR loci with a total sample of 1796 samples of Kazakhs from 16 regions of Kazakhstan. The variability of the Y-chromosome of the Kazakhs in a geographical context can be divided into four main clusters—south, north, east, west. At the same time, in the genetic space of tribal groups, the population of southern Kazakhs clusters with tribes from the same region, and genetic proximity is determined with the populations of the Hazaras of Afghanistan and the Mongols of China. |
| first_indexed | 2024-03-11T15:15:35Z |
| format | Article |
| id | doaj.art-2cddbd2ee71c4be198f387e9376b5d0a |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-03-11T15:15:35Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-2cddbd2ee71c4be198f387e9376b5d0a2023-10-29T12:15:29ZengBMCBMC Genomics1471-21642023-10-0124111410.1186/s12864-023-09753-zGenetic polymorphism of Y-chromosome in Kazakh populations from Southern KazakhstanYeldar Ashirbekov0Madina Seidualy1Arman Abaildayev2Albina Maxutova3Aigul Zhunussova4Ainur Akilzhanova5Kamalidin Sharipov6Zhaxylyk Sabitov7Maxat Zhabagin8M. Aitkhozhin Institute of Molecular Biology and BiochemistryNational Center for BiotechnologyM. Aitkhozhin Institute of Molecular Biology and BiochemistryAstana International UniversityAstana International UniversityNational Laboratory AstanaM. Aitkhozhin Institute of Molecular Biology and BiochemistryResearch Institute for Jochi Ulus StudiesNational Center for BiotechnologyAbstract Background The Kazakhs are one of the biggest Turkic-speaking ethnic groups, controlling vast swaths of land from the Altai to the Caspian Sea. In terms of area, Kazakhstan is ranked ninth in the world. Northern, Eastern, and Western Kazakhstan have already been studied in relation to genetic polymorphism 27 Y-STR. However, current information on the genetic polymorphism of the Y-chromosome of Southern Kazakhstan is limited only by 17 Y-STR and no geographical study of other regions has been studied at this variation. Results The Kazakhstan Y-chromosome Haplotype Reference Database was expanded with 468 Kazakh males from the Zhambyl and Turkestan regions of South Kazakhstan by having their 27 Y-STR loci and 23 Y-SNP markers analyzed. Discrimination capacity (DC = 91.23%), haplotype match probability (HPM = 0.0029) and haplotype diversity (HD = 0.9992) are defined. Most of this Y-chromosome variability is attributed to haplogroups C2a1a1b1-F1756 (2.1%), C2a1a2-M48 (7.3%), C2a1a3-F1918 (33.3%) and C2b1a1a1a-M407 (6%). Median-joining network analysis was applied to understand the relationship between the haplotypes of the three regions. In three genetic layer can be described the position of the populations of the Southern region of Kazakhstan—the geographic Kazakh populations of Kazakhstan, the Kazakh tribal groups, and the people of bordering Asia. Conclusion The Kazakhstan Y-chromosome Haplotype Reference Database was formed for 27 Y-STR loci with a total sample of 1796 samples of Kazakhs from 16 regions of Kazakhstan. The variability of the Y-chromosome of the Kazakhs in a geographical context can be divided into four main clusters—south, north, east, west. At the same time, in the genetic space of tribal groups, the population of southern Kazakhs clusters with tribes from the same region, and genetic proximity is determined with the populations of the Hazaras of Afghanistan and the Mongols of China.https://doi.org/10.1186/s12864-023-09753-zY-STRHaplotypeY-SNPHaplogroupKazakh populationSouthern Kazakhstan |
| spellingShingle | Yeldar Ashirbekov Madina Seidualy Arman Abaildayev Albina Maxutova Aigul Zhunussova Ainur Akilzhanova Kamalidin Sharipov Zhaxylyk Sabitov Maxat Zhabagin Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan BMC Genomics Y-STR Haplotype Y-SNP Haplogroup Kazakh population Southern Kazakhstan |
| title | Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan |
| title_full | Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan |
| title_fullStr | Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan |
| title_full_unstemmed | Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan |
| title_short | Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan |
| title_sort | genetic polymorphism of y chromosome in kazakh populations from southern kazakhstan |
| topic | Y-STR Haplotype Y-SNP Haplogroup Kazakh population Southern Kazakhstan |
| url | https://doi.org/10.1186/s12864-023-09753-z |
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