Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects
Abstract Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material character...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-022-01411-y |
| _version_ | 1811299136193953792 |
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| author | Kai Wu Ali Mohsin Waqas Qamar Zaman Zefei Zhang Wenyan Guan Maoquan Chu Yingping Zhuang Meijin Guo |
| author_facet | Kai Wu Ali Mohsin Waqas Qamar Zaman Zefei Zhang Wenyan Guan Maoquan Chu Yingping Zhuang Meijin Guo |
| author_sort | Kai Wu |
| collection | DOAJ |
| description | Abstract Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. Results In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. Conclusions The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects. Graphical Abstract |
| first_indexed | 2024-04-13T06:30:45Z |
| format | Article |
| id | doaj.art-2cdf9afc1f244cd0a8ae256e99270bd0 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T06:30:45Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-2cdf9afc1f244cd0a8ae256e99270bd02022-12-22T02:58:08ZengBMCJournal of Nanobiotechnology1477-31552022-05-0120112210.1186/s12951-022-01411-yUrchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effectsKai Wu0Ali Mohsin1Waqas Qamar Zaman2Zefei Zhang3Wenyan Guan4Maoquan Chu5Yingping Zhuang6Meijin Guo7State Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyInstitute of Environmental Sciences and Engineering, School of Civil and Environmental Engineering, National University of Sciences and Technology (NUST)Biomedical Multidisciplinary Innovation Research Institute and Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji UniversityMaterials and Biomaterials Science and Engineering, University of CaliforniaBiomedical Multidisciplinary Innovation Research Institute and Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji UniversityState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyState Key Laboratory of Bioreactor Engineering, East China University of Science and TechnologyAbstract Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. Results In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. Conclusions The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01411-yUrchin-like hollow magnetic microspheresLaryngocarcinoma therapyMagneto-mechanic forcePhotothermal effectPhotodynamic effect |
| spellingShingle | Kai Wu Ali Mohsin Waqas Qamar Zaman Zefei Zhang Wenyan Guan Maoquan Chu Yingping Zhuang Meijin Guo Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects Journal of Nanobiotechnology Urchin-like hollow magnetic microspheres Laryngocarcinoma therapy Magneto-mechanic force Photothermal effect Photodynamic effect |
| title | Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects |
| title_full | Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects |
| title_fullStr | Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects |
| title_full_unstemmed | Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects |
| title_short | Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects |
| title_sort | urchin like magnetic microspheres for cancer therapy through synergistic effect of mechanical force photothermal and photodynamic effects |
| topic | Urchin-like hollow magnetic microspheres Laryngocarcinoma therapy Magneto-mechanic force Photothermal effect Photodynamic effect |
| url | https://doi.org/10.1186/s12951-022-01411-y |
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