First-line pembrolizumab plus androgen deprivation therapy for locally advanced microsatellite instability-high prostate cancer in a patient with Muir-Torre syndrome: A case report

First-line pembrolizumab plus androgen deprivation therapy for locally advanced microsatellite instability-high prostate cancer in a patient with Muir-Torre syndrome: A case report

The risks of development of colorectal and endometrial cancers in individuals with Lynch syndrome (LS) are well known and have been widely studied. In recent years, the potential association of other malignancies, including prostate cancer, with LS has been considered. Decision-making regarding scre...

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Bibliographic Details
Main Authors: Mohammad O. Atiq, Danielle M. Pastor, Fatima Karzai, Amy R. Hankin, Baris Turkbey, Lisa M. Cordes, Isaac Brownell, Yi Liu, Gregory T. Chesnut, Ravi A. Madan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
Muir-Torre Syndrome
lynch syndrome
prostate cancer
immunotherapy
microsatellite instability (MSI)
mismatch repair genes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1126476/full

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