Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis
Enantiomerically pure cyclic amino acids are of increasing interest for the life-science industry. To meet this demand, Lonza has developed biotransformation processes with emphasis on the integration of chemistry and biocatalysis for the production of homochiral proline, piperidine-2-carbo...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1999-12-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/3197 |
| _version_ | 1818294985940795392 |
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| author | Michael Petersen Martin Sauter |
| author_facet | Michael Petersen Martin Sauter |
| author_sort | Michael Petersen |
| collection | DOAJ |
| description |
Enantiomerically pure cyclic amino acids are of increasing interest for the life-science industry. To meet this demand, Lonza has developed biotransformation processes with emphasis on the integration of chemistry and biocatalysis for the production of homochiral proline, piperidine-2-carboxylic
acid and piperazine-2-carboxylic acid, and valuable derivatives of these compounds. The processes are designed for use on industrial scale; they have been optimised with respect to availability and cost of starting materials and biocatalyst, productivity of the process and a feasible product
isolation procedure. Because of the extraordinarily high enantioselectivity of the enzymes, the (R)- and the (S)-enantiomers of the unnatural cyclic amino acids, which are both of commercial interest, can be produced in a single reaction. The examples presented demonstrate the
benefit from interdisciplinary research for the production of fine chemicals by the combination of chemistry and biotechnology.
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| first_indexed | 2024-12-13T03:40:27Z |
| format | Article |
| id | doaj.art-2ce1dbb638754c199060d22baa725d1b |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T03:40:27Z |
| publishDate | 1999-12-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-2ce1dbb638754c199060d22baa725d1b2022-12-22T00:00:58ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241999-12-015312Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective BiocatalysisMichael PetersenMartin Sauter Enantiomerically pure cyclic amino acids are of increasing interest for the life-science industry. To meet this demand, Lonza has developed biotransformation processes with emphasis on the integration of chemistry and biocatalysis for the production of homochiral proline, piperidine-2-carboxylic acid and piperazine-2-carboxylic acid, and valuable derivatives of these compounds. The processes are designed for use on industrial scale; they have been optimised with respect to availability and cost of starting materials and biocatalyst, productivity of the process and a feasible product isolation procedure. Because of the extraordinarily high enantioselectivity of the enzymes, the (R)- and the (S)-enantiomers of the unnatural cyclic amino acids, which are both of commercial interest, can be produced in a single reaction. The examples presented demonstrate the benefit from interdisciplinary research for the production of fine chemicals by the combination of chemistry and biotechnology. https://www.chimia.ch/chimia/article/view/3197 |
| spellingShingle | Michael Petersen Martin Sauter Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis CHIMIA |
| title | Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis |
| title_full | Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis |
| title_fullStr | Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis |
| title_full_unstemmed | Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis |
| title_short | Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis |
| title_sort | biotechnology in the fine chemicals industry cyclic amino acids by enantioselective biocatalysis |
| url | https://www.chimia.ch/chimia/article/view/3197 |
| work_keys_str_mv | AT michaelpetersen biotechnologyinthefinechemicalsindustrycyclicaminoacidsbyenantioselectivebiocatalysis AT martinsauter biotechnologyinthefinechemicalsindustrycyclicaminoacidsbyenantioselectivebiocatalysis |