Dopaminergic control of cognitive flexibility in humans and animals
Striatal dopamine is thought to code for learned associations between cues and reinforcers and to mediate approach behavior towards a reward. Less is known about the contribution of dopamine to cognitive flexibility – the ability to adapt behavior in response to changes in the environment. Altered r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00201/full |
| _version_ | 1819053733524275200 |
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| author | Marianne eKlanker Marianne eKlanker Matthijs eFeenstra Matthijs eFeenstra Damiaan eDenys Damiaan eDenys |
| author_facet | Marianne eKlanker Marianne eKlanker Matthijs eFeenstra Matthijs eFeenstra Damiaan eDenys Damiaan eDenys |
| author_sort | Marianne eKlanker |
| collection | DOAJ |
| description | Striatal dopamine is thought to code for learned associations between cues and reinforcers and to mediate approach behavior towards a reward. Less is known about the contribution of dopamine to cognitive flexibility – the ability to adapt behavior in response to changes in the environment. Altered reward processing and impairments in cognitive flexibility are observed in psychiatric disorders such as obsessive compulsive disorder. Patients with this disorder show a disruption of functioning in the frontostriatal circuit and alterations in dopamine signaling. In this review we summarize findings from animal and human studies that have investigated the involvement of striatal dopamine in cognitive flexibility. These findings may provide a better understanding of the role of dopaminergic dysfunction in cognitive inflexibility in psychiatric disorders, such as OCD. |
| first_indexed | 2024-12-21T12:40:25Z |
| format | Article |
| id | doaj.art-2ce254e6e04846e9918ac148693035fb |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T12:40:25Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2ce254e6e04846e9918ac148693035fb2022-12-21T19:03:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-11-01710.3389/fnins.2013.0020156649Dopaminergic control of cognitive flexibility in humans and animalsMarianne eKlanker0Marianne eKlanker1Matthijs eFeenstra2Matthijs eFeenstra3Damiaan eDenys4Damiaan eDenys5Academic Medical CenterNetherlands Institute for NeuroscienceAcademic Medical CenterNetherlands Institute for NeuroscienceAcademic Medical CenterNetherlands Institute for NeuroscienceStriatal dopamine is thought to code for learned associations between cues and reinforcers and to mediate approach behavior towards a reward. Less is known about the contribution of dopamine to cognitive flexibility – the ability to adapt behavior in response to changes in the environment. Altered reward processing and impairments in cognitive flexibility are observed in psychiatric disorders such as obsessive compulsive disorder. Patients with this disorder show a disruption of functioning in the frontostriatal circuit and alterations in dopamine signaling. In this review we summarize findings from animal and human studies that have investigated the involvement of striatal dopamine in cognitive flexibility. These findings may provide a better understanding of the role of dopaminergic dysfunction in cognitive inflexibility in psychiatric disorders, such as OCD.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00201/fullDopamineObsessive-Compulsive DisorderReversal Learningtask switchingcognitive flexibilityset shifting |
| spellingShingle | Marianne eKlanker Marianne eKlanker Matthijs eFeenstra Matthijs eFeenstra Damiaan eDenys Damiaan eDenys Dopaminergic control of cognitive flexibility in humans and animals Frontiers in Neuroscience Dopamine Obsessive-Compulsive Disorder Reversal Learning task switching cognitive flexibility set shifting |
| title | Dopaminergic control of cognitive flexibility in humans and animals |
| title_full | Dopaminergic control of cognitive flexibility in humans and animals |
| title_fullStr | Dopaminergic control of cognitive flexibility in humans and animals |
| title_full_unstemmed | Dopaminergic control of cognitive flexibility in humans and animals |
| title_short | Dopaminergic control of cognitive flexibility in humans and animals |
| title_sort | dopaminergic control of cognitive flexibility in humans and animals |
| topic | Dopamine Obsessive-Compulsive Disorder Reversal Learning task switching cognitive flexibility set shifting |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00201/full |
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