Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives
Squamous cell carcinoma of the head and neck is a complex group of diseases that presents a challenge to the clinician. The prognosis in the recurrent/metastatic disease is particularly dismal, with a median survival of approximately 12 months. Recently, the personalized and multimodal approach has...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1288695/full |
| _version_ | 1827391225097879552 |
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| author | Sergio Pannunzio Armando Di Bello Denis Occhipinti Alessandro Scala Gloria Messina Giustina Valente Michela Quirino Mariantonietta Di Salvatore Giampaolo Tortora Giampaolo Tortora Alessandra Cassano Alessandra Cassano |
| author_facet | Sergio Pannunzio Armando Di Bello Denis Occhipinti Alessandro Scala Gloria Messina Giustina Valente Michela Quirino Mariantonietta Di Salvatore Giampaolo Tortora Giampaolo Tortora Alessandra Cassano Alessandra Cassano |
| author_sort | Sergio Pannunzio |
| collection | DOAJ |
| description | Squamous cell carcinoma of the head and neck is a complex group of diseases that presents a challenge to the clinician. The prognosis in the recurrent/metastatic disease is particularly dismal, with a median survival of approximately 12 months. Recently, the personalized and multimodal approach has increased prognosis by integrating locoregional strategies (salvage surgery and stereotactic radiotherapy) and systemic treatments (chemotherapy, immunotherapy, and target therapy). Malnutrition is a significant clinical problem that interferes with dose intensity, and thus, feeding supplementation is critical not only to increase the quality of life but also to improve overall survival. With this review, we want to emphasize the importance of the multidisciplinary approach, quality of life, and nutritional supportive care and to integrate the latest updates of predictive biomarkers for immunotherapy and future therapeutic strategies. |
| first_indexed | 2024-03-08T17:07:35Z |
| format | Article |
| id | doaj.art-2ce31066479542818aef9d43af60346d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T17:07:35Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2ce31066479542818aef9d43af60346d2024-01-04T04:31:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.12886951288695Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectivesSergio Pannunzio0Armando Di Bello1Denis Occhipinti2Alessandro Scala3Gloria Messina4Giustina Valente5Michela Quirino6Mariantonietta Di Salvatore7Giampaolo Tortora8Giampaolo Tortora9Alessandra Cassano10Alessandra Cassano11Oncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyComprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyOncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Roma, ItalyComprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalySquamous cell carcinoma of the head and neck is a complex group of diseases that presents a challenge to the clinician. The prognosis in the recurrent/metastatic disease is particularly dismal, with a median survival of approximately 12 months. Recently, the personalized and multimodal approach has increased prognosis by integrating locoregional strategies (salvage surgery and stereotactic radiotherapy) and systemic treatments (chemotherapy, immunotherapy, and target therapy). Malnutrition is a significant clinical problem that interferes with dose intensity, and thus, feeding supplementation is critical not only to increase the quality of life but also to improve overall survival. With this review, we want to emphasize the importance of the multidisciplinary approach, quality of life, and nutritional supportive care and to integrate the latest updates of predictive biomarkers for immunotherapy and future therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fonc.2023.1288695/fullhead and necksquamous cell carcinomarecurrentmetastaticmultimodality treatmentsurgery |
| spellingShingle | Sergio Pannunzio Armando Di Bello Denis Occhipinti Alessandro Scala Gloria Messina Giustina Valente Michela Quirino Mariantonietta Di Salvatore Giampaolo Tortora Giampaolo Tortora Alessandra Cassano Alessandra Cassano Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives Frontiers in Oncology head and neck squamous cell carcinoma recurrent metastatic multimodality treatment surgery |
| title | Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives |
| title_full | Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives |
| title_fullStr | Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives |
| title_full_unstemmed | Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives |
| title_short | Multimodality treatment in recurrent/metastatic squamous cell carcinoma of head and neck: current therapy, challenges, and future perspectives |
| title_sort | multimodality treatment in recurrent metastatic squamous cell carcinoma of head and neck current therapy challenges and future perspectives |
| topic | head and neck squamous cell carcinoma recurrent metastatic multimodality treatment surgery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1288695/full |
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