Sensing acidosis: nociception or sngception?
Abstract Background Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. Main body In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset m...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12929-018-0486-5 |
| _version_ | 1818925881707462656 |
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| author | Jiann-Her Lin Chih-Hsien Hung Der-Sheng Han Shih-Ting Chen Cheng-Han Lee Wei-Zen Sun Chih-Cheng Chen |
| author_facet | Jiann-Her Lin Chih-Hsien Hung Der-Sheng Han Shih-Ting Chen Cheng-Han Lee Wei-Zen Sun Chih-Cheng Chen |
| author_sort | Jiann-Her Lin |
| collection | DOAJ |
| description | Abstract Background Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. Main body In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called “sngception (sng- ception)” to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. “Sng” is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore. Conclusion Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception. |
| first_indexed | 2024-12-20T02:48:16Z |
| format | Article |
| id | doaj.art-2ce45c716c424224a44e6b12ca2af82a |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-12-20T02:48:16Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-2ce45c716c424224a44e6b12ca2af82a2022-12-21T19:56:06ZengBMCJournal of Biomedical Science1423-01272018-11-012511810.1186/s12929-018-0486-5Sensing acidosis: nociception or sngception?Jiann-Her Lin0Chih-Hsien Hung1Der-Sheng Han2Shih-Ting Chen3Cheng-Han Lee4Wei-Zen Sun5Chih-Cheng Chen6Institute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaDepartment of Physical Medicine and Rehabilitation, National Taiwan University HospitalInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaDepartment of Anesthesiology, National Taiwan University HospitalInstitute of Biomedical Sciences, Academia SinicaAbstract Background Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli. Main body In the pain clinic, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. However, soreness sensation is a sign of successful analgesia for acupuncture and noxipoint therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a concept called “sngception (sng- ception)” to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception. “Sng” is a Taiwanese word that represents the state of soreness while at the same time imitates the natural vocalization of humans feeling sore. Conclusion Here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system. Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception.http://link.springer.com/article/10.1186/s12929-018-0486-5AcidosisASIC3NociceptionPainSngceptionSoreness |
| spellingShingle | Jiann-Her Lin Chih-Hsien Hung Der-Sheng Han Shih-Ting Chen Cheng-Han Lee Wei-Zen Sun Chih-Cheng Chen Sensing acidosis: nociception or sngception? Journal of Biomedical Science Acidosis ASIC3 Nociception Pain Sngception Soreness |
| title | Sensing acidosis: nociception or sngception? |
| title_full | Sensing acidosis: nociception or sngception? |
| title_fullStr | Sensing acidosis: nociception or sngception? |
| title_full_unstemmed | Sensing acidosis: nociception or sngception? |
| title_short | Sensing acidosis: nociception or sngception? |
| title_sort | sensing acidosis nociception or sngception |
| topic | Acidosis ASIC3 Nociception Pain Sngception Soreness |
| url | http://link.springer.com/article/10.1186/s12929-018-0486-5 |
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