Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study
Background and Aim: Observational studies have demonstrated that the risk of developing multiple sclerosis (MS) is associated with vitamin D (25(OH)D) status. However, there is no local study regarding vitamin D status in MS patients in the South Khorasan. Therefore, present study aimed at comparing...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2017-05-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
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| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-1975-1&slc_lang=en&sid=1 |
| _version_ | 1818534780841492480 |
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| author | Masoumeh Zarezadeh Mohammad Dehghani Firoozabadi Asghar Zarban Gholamreza Sharifzadeh Maryam Valavi |
| author_facet | Masoumeh Zarezadeh Mohammad Dehghani Firoozabadi Asghar Zarban Gholamreza Sharifzadeh Maryam Valavi |
| author_sort | Masoumeh Zarezadeh |
| collection | DOAJ |
| description | Background and Aim: Observational studies have demonstrated that the risk of developing multiple sclerosis (MS) is associated with vitamin D (25(OH)D) status. However, there is no local study regarding vitamin D status in MS patients in the South Khorasan. Therefore, present study aimed at comparing the serum levels of vitamin D between the South Khorasan MS patients and healthy subjects, and determining its association with disability in these patients.
Materials and Methods: In this case-control study a total of 144 individuals (72 previously diagnosed MS cases and 72 age and sex matched healthy controls) were included. Demographic characteristics and serum vitamin D levels of both groups as well as Expanded Disability Status Scale (EDSS) for MS patients were assessed. The obtained data was analyzed using t-test, Mann Whitney U test, Chi-square, and Pearson's correlation coefficient test applying SPSS software.
Results: There was a significant difference (P<0.0001) in vitamin D levels between the case (47.4±5.4ng/mL) and the control (14.66±10.4 ng/mL) groups. A direct association was found between vitamin D levels and EDSS in MS patients (P<0.0001), too.
Conclusion: Surprisingly, it was found that vitamin D level was significantly higher in MS patients than the controls. There was a significant positive association between the level of vitamin D and disability status in patients with MS. The association may be due to more administration of vitamin D supplement to MS patients. |
| first_indexed | 2024-12-11T18:16:02Z |
| format | Article |
| id | doaj.art-2ce4728fe769448eaf4d7a54af20e53c |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-12-11T18:16:02Z |
| publishDate | 2017-05-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-2ce4728fe769448eaf4d7a54af20e53c2022-12-22T00:55:25ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522017-05-012412835Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control studyMasoumeh Zarezadeh0Mohammad Dehghani Firoozabadi1Asghar Zarban2Gholamreza Sharifzadeh3Maryam Valavi4 Member of Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Department of Neurology, Faculty of Medicine, Birjand University of medical science, Birjand, Iran. Birjand CardioVascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinant of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Member of Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Background and Aim: Observational studies have demonstrated that the risk of developing multiple sclerosis (MS) is associated with vitamin D (25(OH)D) status. However, there is no local study regarding vitamin D status in MS patients in the South Khorasan. Therefore, present study aimed at comparing the serum levels of vitamin D between the South Khorasan MS patients and healthy subjects, and determining its association with disability in these patients. Materials and Methods: In this case-control study a total of 144 individuals (72 previously diagnosed MS cases and 72 age and sex matched healthy controls) were included. Demographic characteristics and serum vitamin D levels of both groups as well as Expanded Disability Status Scale (EDSS) for MS patients were assessed. The obtained data was analyzed using t-test, Mann Whitney U test, Chi-square, and Pearson's correlation coefficient test applying SPSS software. Results: There was a significant difference (P<0.0001) in vitamin D levels between the case (47.4±5.4ng/mL) and the control (14.66±10.4 ng/mL) groups. A direct association was found between vitamin D levels and EDSS in MS patients (P<0.0001), too. Conclusion: Surprisingly, it was found that vitamin D level was significantly higher in MS patients than the controls. There was a significant positive association between the level of vitamin D and disability status in patients with MS. The association may be due to more administration of vitamin D supplement to MS patients.http://journal.bums.ac.ir/browse.php?a_code=A-10-1975-1&slc_lang=en&sid=1Multiple Sclerosis EDSS Vitamin D. |
| spellingShingle | Masoumeh Zarezadeh Mohammad Dehghani Firoozabadi Asghar Zarban Gholamreza Sharifzadeh Maryam Valavi Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study مجله دانشگاه علوم پزشکی بیرجند Multiple Sclerosis EDSS Vitamin D. |
| title | Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study |
| title_full | Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study |
| title_fullStr | Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study |
| title_full_unstemmed | Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study |
| title_short | Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study |
| title_sort | vitamin d status among multiple sclerosis patients in south khorasan a case control study |
| topic | Multiple Sclerosis EDSS Vitamin D. |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-1975-1&slc_lang=en&sid=1 |
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