Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke
Abstract Background Host inflammation has been studied in patients with ischemic stroke (IS) due to large vessel occlusions. Inflammatory markers were shown to correlate with large artery atherosclerosis and worse outcomes after ischemic stroke due to large vessel occlusions. However, the associatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00478-6 |
| _version_ | 1828791123219316736 |
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| author | Sevda Diker Pınar Gelener Amber Eker Bahar Kaymakamzade Senem Mut Ayşegül Erem Uğurcan Balyemez |
| author_facet | Sevda Diker Pınar Gelener Amber Eker Bahar Kaymakamzade Senem Mut Ayşegül Erem Uğurcan Balyemez |
| author_sort | Sevda Diker |
| collection | DOAJ |
| description | Abstract Background Host inflammation has been studied in patients with ischemic stroke (IS) due to large vessel occlusions. Inflammatory markers were shown to correlate with large artery atherosclerosis and worse outcomes after ischemic stroke due to large vessel occlusions. However, the association between inflammation and cerebral small vessel disease (SVD) is controversial. Mostly studied are the white matter hyperintensities; however, results regarding association of white matter hyperintensities with inflammatory markers are conflicting. We aimed to investigate the association between cerebral microbleed (CMB) load, as an indicator of SVD, and inflammation indices in patients with IS. Results We identified 127 patients with IS admitted within 7 days of symptom onset. CMBs were detected in 37% (n: 47) of patients. Patient’s age and Fazekas score were independently associated with CMB load. Inflammatory biomarkers were not associated with the presence or quantitative burden of CMBs. Conclusions White matter damage and patient’s age predicted CMB presence and number, respectively, in IS patients. However, inflammatory markers failed to show any association with such SVD signs. Prospective studies with a higher number of stroke patients are needed in order to justify our findings. |
| first_indexed | 2024-12-12T02:45:15Z |
| format | Article |
| id | doaj.art-2ce4b4c88c314730b51665a261a045c4 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-12T02:45:15Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-2ce4b4c88c314730b51665a261a045c42022-12-22T00:41:04ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-05-015811910.1186/s41983-022-00478-6Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic strokeSevda Diker0Pınar Gelener1Amber Eker2Bahar Kaymakamzade3Senem Mut4Ayşegül Erem5Uğurcan Balyemez6Department of Neurology, Faculty of Medicine, Cyprus International UniversityDepartment of Neurology, Faculty of Medicine, University of KyreniaDepartment of Neurology, Faculty of Medicine, Eastern Mediterranean UniveristyDepartment of Neurology, Faculty of Medicine, Near East UniversityDepartment of Neurology, Faculty of Medicine, University of KyreniaDepartment of Basic Sciences & Humanities, Faculty of Arts & Sciences, Cyprus International UniversityDepartment of Radiology, Faculty of Medicine, Near East UniversityAbstract Background Host inflammation has been studied in patients with ischemic stroke (IS) due to large vessel occlusions. Inflammatory markers were shown to correlate with large artery atherosclerosis and worse outcomes after ischemic stroke due to large vessel occlusions. However, the association between inflammation and cerebral small vessel disease (SVD) is controversial. Mostly studied are the white matter hyperintensities; however, results regarding association of white matter hyperintensities with inflammatory markers are conflicting. We aimed to investigate the association between cerebral microbleed (CMB) load, as an indicator of SVD, and inflammation indices in patients with IS. Results We identified 127 patients with IS admitted within 7 days of symptom onset. CMBs were detected in 37% (n: 47) of patients. Patient’s age and Fazekas score were independently associated with CMB load. Inflammatory biomarkers were not associated with the presence or quantitative burden of CMBs. Conclusions White matter damage and patient’s age predicted CMB presence and number, respectively, in IS patients. However, inflammatory markers failed to show any association with such SVD signs. Prospective studies with a higher number of stroke patients are needed in order to justify our findings.https://doi.org/10.1186/s41983-022-00478-6Cerebral microbleedFazekasInflammatory markerStroke |
| spellingShingle | Sevda Diker Pınar Gelener Amber Eker Bahar Kaymakamzade Senem Mut Ayşegül Erem Uğurcan Balyemez Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Cerebral microbleed Fazekas Inflammatory marker Stroke |
| title | Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| title_full | Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| title_fullStr | Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| title_full_unstemmed | Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| title_short | Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| title_sort | association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke |
| topic | Cerebral microbleed Fazekas Inflammatory marker Stroke |
| url | https://doi.org/10.1186/s41983-022-00478-6 |
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