Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study
Abstract Background Childbearing-aged female patients and elderly patients with bipolar disorder need special attention for pharmacological treatments, but current guidelines provide little information on their pharmacological treatment. In particular, the risk/benefit balance of pharmacological tre...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Annals of General Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12991-022-00415-0 |
| _version_ | 1811267676313485312 |
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| author | Yasushi Kawamata Norio Yasui-Furukori Naoto Adachi Hitoshi Ueda Seiji Hongo Takaharu Azekawa Yukihisa Kubota Eiichi Katsumoto Koji Edagawa Eiichiro Goto Kazuhira Miki Masaki Kato Atsuo Nakagawa Toshiaki Kikuchi Takashi Tsuboi Reiji Yoshimura Kazutaka Shimoda Koichiro Watanabe |
| author_facet | Yasushi Kawamata Norio Yasui-Furukori Naoto Adachi Hitoshi Ueda Seiji Hongo Takaharu Azekawa Yukihisa Kubota Eiichi Katsumoto Koji Edagawa Eiichiro Goto Kazuhira Miki Masaki Kato Atsuo Nakagawa Toshiaki Kikuchi Takashi Tsuboi Reiji Yoshimura Kazutaka Shimoda Koichiro Watanabe |
| author_sort | Yasushi Kawamata |
| collection | DOAJ |
| description | Abstract Background Childbearing-aged female patients and elderly patients with bipolar disorder need special attention for pharmacological treatments, but current guidelines provide little information on their pharmacological treatment. In particular, the risk/benefit balance of pharmacological treatment for childbearing-aged females with bipolar disorder is a growing concern. Therefore, we aimed to address the effect of age and sex on psychotropic drug prescription for outpatients with bipolar disorder. Methods The MUlticenter treatment SUrvey for BIpolar disorder in Japanese psychiatric clinics (MUSUBI) study was conducted, and data on age, sex, and details of pharmacological treatment were collected. Results A total of 3106 outpatients were included in this study. Among young females (age ≤ 39), 25% were prescribed valproate. There was no significant difference in the frequency and daily dose of valproate prescription for young females among all groups. Valproate prescriptions were significantly less frequent among young males and more frequent among middle-aged males. Lithium prescriptions were significantly less frequent among young females and more frequent among older males (age ≥ 65) and older females. Lamotrigine prescriptions were significantly more frequent among young males and young females and less frequent among older males and older females. Carbamazepine prescriptions were significantly less frequent among young males and more frequent among older males. Conclusions Biased information about the risk and safety of valproate and lithium for young females was suggested, and further study to correct this bias is needed. Older patients were prescribed lithium more commonly than lamotrigine. Further studies are needed to determine the actual pharmacotherapy for elderly individuals. |
| first_indexed | 2024-04-12T21:06:54Z |
| format | Article |
| id | doaj.art-2ce53df075954b1ba88c61cc6a2f5bda |
| institution | Directory Open Access Journal |
| issn | 1744-859X |
| language | English |
| last_indexed | 2024-04-12T21:06:54Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of General Psychiatry |
| spelling | doaj.art-2ce53df075954b1ba88c61cc6a2f5bda2022-12-22T03:16:41ZengBMCAnnals of General Psychiatry1744-859X2022-09-0121111110.1186/s12991-022-00415-0Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional studyYasushi Kawamata0Norio Yasui-Furukori1Naoto Adachi2Hitoshi Ueda3Seiji Hongo4Takaharu Azekawa5Yukihisa Kubota6Eiichi Katsumoto7Koji Edagawa8Eiichiro Goto9Kazuhira Miki10Masaki Kato11Atsuo Nakagawa12Toshiaki Kikuchi13Takashi Tsuboi14Reiji Yoshimura15Kazutaka Shimoda16Koichiro Watanabe17Department of Psychiatry, Dokkyo Medical University School of MedicineDepartment of Psychiatry, Dokkyo Medical University School of MedicineThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsThe Japanese Association of Neuro-Psychiatric ClinicsDepartment of Neuropsychiatry, Kansai Medical UniversityDepartment of Neuropsychiatry, Keio University School of MedicineDepartment of Neuropsychiatry, Keio University School of MedicineDepartment of Neuropsychiatry, Kyorin University School of MedicineDepartment of Psychiatry, University of Occupational and Environmental HealthDepartment of Psychiatry, Dokkyo Medical University School of MedicineDepartment of Neuropsychiatry, Kyorin University School of MedicineAbstract Background Childbearing-aged female patients and elderly patients with bipolar disorder need special attention for pharmacological treatments, but current guidelines provide little information on their pharmacological treatment. In particular, the risk/benefit balance of pharmacological treatment for childbearing-aged females with bipolar disorder is a growing concern. Therefore, we aimed to address the effect of age and sex on psychotropic drug prescription for outpatients with bipolar disorder. Methods The MUlticenter treatment SUrvey for BIpolar disorder in Japanese psychiatric clinics (MUSUBI) study was conducted, and data on age, sex, and details of pharmacological treatment were collected. Results A total of 3106 outpatients were included in this study. Among young females (age ≤ 39), 25% were prescribed valproate. There was no significant difference in the frequency and daily dose of valproate prescription for young females among all groups. Valproate prescriptions were significantly less frequent among young males and more frequent among middle-aged males. Lithium prescriptions were significantly less frequent among young females and more frequent among older males (age ≥ 65) and older females. Lamotrigine prescriptions were significantly more frequent among young males and young females and less frequent among older males and older females. Carbamazepine prescriptions were significantly less frequent among young males and more frequent among older males. Conclusions Biased information about the risk and safety of valproate and lithium for young females was suggested, and further study to correct this bias is needed. Older patients were prescribed lithium more commonly than lamotrigine. Further studies are needed to determine the actual pharmacotherapy for elderly individuals.https://doi.org/10.1186/s12991-022-00415-0ValproateMood stabilizerChildbearing ageElderlyReal worldOutpatients |
| spellingShingle | Yasushi Kawamata Norio Yasui-Furukori Naoto Adachi Hitoshi Ueda Seiji Hongo Takaharu Azekawa Yukihisa Kubota Eiichi Katsumoto Koji Edagawa Eiichiro Goto Kazuhira Miki Masaki Kato Atsuo Nakagawa Toshiaki Kikuchi Takashi Tsuboi Reiji Yoshimura Kazutaka Shimoda Koichiro Watanabe Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study Annals of General Psychiatry Valproate Mood stabilizer Childbearing age Elderly Real world Outpatients |
| title | Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study |
| title_full | Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study |
| title_fullStr | Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study |
| title_full_unstemmed | Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study |
| title_short | Effect of age and sex on prescriptions for outpatients with bipolar disorder in the MUSUBI study: a cross‑sectional study |
| title_sort | effect of age and sex on prescriptions for outpatients with bipolar disorder in the musubi study a cross sectional study |
| topic | Valproate Mood stabilizer Childbearing age Elderly Real world Outpatients |
| url | https://doi.org/10.1186/s12991-022-00415-0 |
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