Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement

Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement

A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he...

Full description

Bibliographic Details
Main Authors: Takeharu Kato, Hidehiro Itonaga, Jun Taguchi, Junya Makiyama, Machiko Fujioka, Masataka Taguchi, Makiko Horai, Yasushi Sawayama, Daisuke Niino, Yoshitaka Imaizumi, Tomoko Hata, Shinichiro Yoshida, Kana Sakamoto, Kengo Takeuchi, Koichi Ohshima, Yasushi Miyazaki
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048918300633
Description
Summary:A 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission following re-induction therapy, he underwent a second BMT from another unrelated donor, and experienced complete remission with grade II acute graft-versus-host disease and moderate chronic graft-versus-host disease. He remains alive in complete remission more than 71 months after the second BMT. These results suggested that donor change at the second transplantation may represent a considerable therapeutic option for patients with relapsed BPDCN. Keywords: Blastic plasmacytoid dendritic cell neoplasm, Allogeneic hematopoietic stem cell transplantation, Donor change, MYC rearrangement
ISSN:2213-0489

Similar Items