Treatment of painful diabetic neuropathy

Painful diabetic neuropathy is observed in almost half of patients with diabetes mellitus (DM) and is associated with a decrease in the quality of life, emotional disorders, sleep disorders. The achievement and maintenance of the normal level of glucose in the blood is the basis for the prevention a...

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Main Authors: Vladimir A. Parfenov, Mariya V. Konyashova
Format: Article
Language:Russian
Published: ZAO "Consilium Medicum" 2021-11-01
Series:Consilium Medicum
Subjects:
Online Access:https://consilium.orscience.ru/2075-1753/article/viewFile/96615/70888
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author Vladimir A. Parfenov
Mariya V. Konyashova
author_facet Vladimir A. Parfenov
Mariya V. Konyashova
author_sort Vladimir A. Parfenov
collection DOAJ
description Painful diabetic neuropathy is observed in almost half of patients with diabetes mellitus (DM) and is associated with a decrease in the quality of life, emotional disorders, sleep disorders. The achievement and maintenance of the normal level of glucose in the blood is the basis for the prevention and treatment of DM, but this often does not allow the patient from pain and other clinical manifestations of neuropathy. Drug diabetic neuropathy therapy methods are discussed, the results of randomized placebo controlled studies on the efficiency and side effects of various drugs are analyzed. It is noted that pregabalin and gabapenitin, as antidepressants duloxetin, venlafaxin and amitriptyline, are most effective as anti-epileptic agents. In our country, with painful diabetic neuropathy, the preparations of a-lipoic acid are widely used. Analyzed data on efficacy and complications of the use of transcutaneus electrical nerves stimulation and spinal cord stimulation with pain diabetic neuropathy refractory to drug therapy. It is noted that many patients with pain diabetic neuropathy have combined diseases, detection and effective treatment of which can lead to an improvement in the state of patients and reduce the manifestations of neuropathy.
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spelling doaj.art-2ce61be29ed641fe86cfd0c746f625be2022-12-22T00:04:09ZrusZAO "Consilium Medicum"Consilium Medicum2075-17532542-21702021-11-01231184184610.26442/20751753.2021.11.2012304323Treatment of painful diabetic neuropathyVladimir A. Parfenov0https://orcid.org/0000-0002-1992-7960Mariya V. Konyashova1https://orcid.org/0000-0002-3667-7959Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Painful diabetic neuropathy is observed in almost half of patients with diabetes mellitus (DM) and is associated with a decrease in the quality of life, emotional disorders, sleep disorders. The achievement and maintenance of the normal level of glucose in the blood is the basis for the prevention and treatment of DM, but this often does not allow the patient from pain and other clinical manifestations of neuropathy. Drug diabetic neuropathy therapy methods are discussed, the results of randomized placebo controlled studies on the efficiency and side effects of various drugs are analyzed. It is noted that pregabalin and gabapenitin, as antidepressants duloxetin, venlafaxin and amitriptyline, are most effective as anti-epileptic agents. In our country, with painful diabetic neuropathy, the preparations of a-lipoic acid are widely used. Analyzed data on efficacy and complications of the use of transcutaneus electrical nerves stimulation and spinal cord stimulation with pain diabetic neuropathy refractory to drug therapy. It is noted that many patients with pain diabetic neuropathy have combined diseases, detection and effective treatment of which can lead to an improvement in the state of patients and reduce the manifestations of neuropathy.https://consilium.orscience.ru/2075-1753/article/viewFile/96615/70888painful diabetic neuropathypregabalingabapentineneurotineduloxetinevenlafaxinecapsacina-lipoic acid preparationsthioctacidpercutaneous electrical stimulation of nervesspinal cord stimulation
spellingShingle Vladimir A. Parfenov
Mariya V. Konyashova
Treatment of painful diabetic neuropathy
Consilium Medicum
painful diabetic neuropathy
pregabalin
gabapentine
neurotine
duloxetine
venlafaxine
capsacin
a-lipoic acid preparations
thioctacid
percutaneous electrical stimulation of nerves
spinal cord stimulation
title Treatment of painful diabetic neuropathy
title_full Treatment of painful diabetic neuropathy
title_fullStr Treatment of painful diabetic neuropathy
title_full_unstemmed Treatment of painful diabetic neuropathy
title_short Treatment of painful diabetic neuropathy
title_sort treatment of painful diabetic neuropathy
topic painful diabetic neuropathy
pregabalin
gabapentine
neurotine
duloxetine
venlafaxine
capsacin
a-lipoic acid preparations
thioctacid
percutaneous electrical stimulation of nerves
spinal cord stimulation
url https://consilium.orscience.ru/2075-1753/article/viewFile/96615/70888
work_keys_str_mv AT vladimiraparfenov treatmentofpainfuldiabeticneuropathy
AT mariyavkonyashova treatmentofpainfuldiabeticneuropathy