Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients
The aim of this study was to evaluate the role of nephrotic syndrome 2 (NPHS2) gene polymorphism (R229Q) in chronic kidney disease which has unclear etiology. This study was conducted on 80 CKD patients compared with 40 age and sex matched normal volunteers acting as a control group. All of them und...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Beni-Suef University, Faculty of Medicine
2021-06-01
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| Series: | Egyptian Journal of Medical Research |
| Subjects: | |
| Online Access: | https://ejmr.journals.ekb.eg/article_174556_0ad47ed2b4b879ff94aafb9bc55b8cda.pdf |
| Summary: | The aim of this study was to evaluate the role of nephrotic syndrome 2 (NPHS2) gene polymorphism (R229Q) in chronic kidney disease which has unclear etiology.
This study was conducted on 80 CKD patients compared with 40 age and sex matched normal volunteers acting as a control group. All of them underwent renal function tests and were assessed for the presence of NPHS2 gene polymorphism. We noticed that (R229Q) is a common variant in Egyptian population. Its concentration was (62.5%) in CKD patients and (55%) in control group. There was no significant difference with p-value > 0.05 between patients and control groups as regards to NPHS2 genotypes and alleles. |
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| ISSN: | 2682-4396 2682-440X |