Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet
Introduction: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeast rice is known to have lipid lowering effects. Combination of red yeast rice with various oils is taken by different population around the world. Aim: In this present work,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7624/18623_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Dietary supplements provide a novel population
based health approach for treating hyperlipidemias. Red yeast
rice is known to have lipid lowering effects. Combination of red
yeast rice with various oils is taken by different population around
the world.
Aim: In this present work, we aimed to compare the effects of red
yeast rice with different oil (coconut, rice bran and sunflower oil)
supplementations on lipid levels and oxidative stress in rats fed
on hypercholesterolemic diet.
Materials and Methods: A Randomized controlled study
was conducted on 28 male Sprague Dawley rats. It included
4 arms-Control arm (hypercholesterolemic diet), Test arm A
(hypercholesterolemic diet +Red yeast rice + Rice bran oil), arm
B (hypercholesterolemic diet +Red yeast rice + Coconut oil) and
arm C (hypercholesterolemic diet +Red yeast rice + Sunflower
oil). At the end of one month, serum cholesterol, triglycerides,
MDA and paraoxonase was measured. The mean values of
analytes between the different groups were compared using
student ‘t-’ test.
Results: The rats fed with red yeast rice and rice bran oil combination showed significantly lower levels of serum cholesterol,
triglycerides and MDA when compared to the controls. The
serum paraoxonase levels were significantly higher in this group
when compared to the controls. The rats fed with red yeast rice
and coconut oil combination showed significantly lower serum
cholesterol and MDA levels when compared to the controls.
The mean triglyceride and paraoxonase levels did not show any
statistically significant difference from the controls. The rats on
red yeast rice and sunflower oil combination did not show any
statistically significant difference in the lipid levels and oxidative
stress parameters.
Conclusion: The food combination which had best outcome
in preventing the development of hyperlipidemia and oxidative
stress in rats fed with hypercholesterolemic diet was red yeast
rice and rice bran oil. Combining red yeast rice with coconut oil
and sunflower oil gave suboptimal benefits. |
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| ISSN: | 2249-782X 0973-709X |