Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet
Introduction: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeast rice is known to have lipid lowering effects. Combination of red yeast rice with various oils is taken by different population around the world. Aim: In this present work,...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7624/18623_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1818188347292516352 |
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| author | Sumitra Govindarajan Kishore Vellingiri |
| author_facet | Sumitra Govindarajan Kishore Vellingiri |
| author_sort | Sumitra Govindarajan |
| collection | DOAJ |
| description | Introduction: Dietary supplements provide a novel population
based health approach for treating hyperlipidemias. Red yeast
rice is known to have lipid lowering effects. Combination of red
yeast rice with various oils is taken by different population around
the world.
Aim: In this present work, we aimed to compare the effects of red
yeast rice with different oil (coconut, rice bran and sunflower oil)
supplementations on lipid levels and oxidative stress in rats fed
on hypercholesterolemic diet.
Materials and Methods: A Randomized controlled study
was conducted on 28 male Sprague Dawley rats. It included
4 arms-Control arm (hypercholesterolemic diet), Test arm A
(hypercholesterolemic diet +Red yeast rice + Rice bran oil), arm
B (hypercholesterolemic diet +Red yeast rice + Coconut oil) and
arm C (hypercholesterolemic diet +Red yeast rice + Sunflower
oil). At the end of one month, serum cholesterol, triglycerides,
MDA and paraoxonase was measured. The mean values of
analytes between the different groups were compared using
student ‘t-’ test.
Results: The rats fed with red yeast rice and rice bran oil combination showed significantly lower levels of serum cholesterol,
triglycerides and MDA when compared to the controls. The
serum paraoxonase levels were significantly higher in this group
when compared to the controls. The rats fed with red yeast rice
and coconut oil combination showed significantly lower serum
cholesterol and MDA levels when compared to the controls.
The mean triglyceride and paraoxonase levels did not show any
statistically significant difference from the controls. The rats on
red yeast rice and sunflower oil combination did not show any
statistically significant difference in the lipid levels and oxidative
stress parameters.
Conclusion: The food combination which had best outcome
in preventing the development of hyperlipidemia and oxidative
stress in rats fed with hypercholesterolemic diet was red yeast
rice and rice bran oil. Combining red yeast rice with coconut oil
and sunflower oil gave suboptimal benefits. |
| first_indexed | 2024-12-11T23:25:29Z |
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| id | doaj.art-2ce8b763dab94eff81383d97253bb077 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T23:25:29Z |
| publishDate | 2016-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-2ce8b763dab94eff81383d97253bb0772022-12-22T00:46:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-04-01104BF05BF0710.7860/JCDR/2016/18623.7624Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic DietSumitra Govindarajan0Kishore Vellingiri1Assistant Professor, Department of Biochemistry, PSG IMSR, Coimbatore, India.Student, PSG IMSR, Coimbatore, India.Introduction: Dietary supplements provide a novel population based health approach for treating hyperlipidemias. Red yeast rice is known to have lipid lowering effects. Combination of red yeast rice with various oils is taken by different population around the world. Aim: In this present work, we aimed to compare the effects of red yeast rice with different oil (coconut, rice bran and sunflower oil) supplementations on lipid levels and oxidative stress in rats fed on hypercholesterolemic diet. Materials and Methods: A Randomized controlled study was conducted on 28 male Sprague Dawley rats. It included 4 arms-Control arm (hypercholesterolemic diet), Test arm A (hypercholesterolemic diet +Red yeast rice + Rice bran oil), arm B (hypercholesterolemic diet +Red yeast rice + Coconut oil) and arm C (hypercholesterolemic diet +Red yeast rice + Sunflower oil). At the end of one month, serum cholesterol, triglycerides, MDA and paraoxonase was measured. The mean values of analytes between the different groups were compared using student ‘t-’ test. Results: The rats fed with red yeast rice and rice bran oil combination showed significantly lower levels of serum cholesterol, triglycerides and MDA when compared to the controls. The serum paraoxonase levels were significantly higher in this group when compared to the controls. The rats fed with red yeast rice and coconut oil combination showed significantly lower serum cholesterol and MDA levels when compared to the controls. The mean triglyceride and paraoxonase levels did not show any statistically significant difference from the controls. The rats on red yeast rice and sunflower oil combination did not show any statistically significant difference in the lipid levels and oxidative stress parameters. Conclusion: The food combination which had best outcome in preventing the development of hyperlipidemia and oxidative stress in rats fed with hypercholesterolemic diet was red yeast rice and rice bran oil. Combining red yeast rice with coconut oil and sunflower oil gave suboptimal benefits.https://jcdr.net/articles/PDF/7624/18623_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdfcholesterolhyperlipidemialipid peroxidationmdaparaoxonasetriglyceride |
| spellingShingle | Sumitra Govindarajan Kishore Vellingiri Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet Journal of Clinical and Diagnostic Research cholesterol hyperlipidemia lipid peroxidation mda paraoxonase triglyceride |
| title | Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet |
| title_full | Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet |
| title_fullStr | Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet |
| title_full_unstemmed | Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet |
| title_short | Effect of Red Yeast Rice and Coconut, Rice Bran or Sunflower Oil Combination in Rats on Hypercholesterolemic Diet |
| title_sort | effect of red yeast rice and coconut rice bran or sunflower oil combination in rats on hypercholesterolemic diet |
| topic | cholesterol hyperlipidemia lipid peroxidation mda paraoxonase triglyceride |
| url | https://jcdr.net/articles/PDF/7624/18623_CE(RA1)_F(T)_PF1(RSAK)_PFA(AK)_PF2(PAG).pdf |
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