Cytokine profile associated with human chronic schistosomiasis mansoni
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2004-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004 |
| _version_ | 1797757673235546112 |
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| author | Andréa Magalhães Delfin Gonzalez Miranda Roberval Gonzalez Miranda Maria Ilma Araújo Adriana Almeida de Jesus Angela Silva Luciana B Santana Edward Pearce Edgar M Carvalho Amélia Ribeiro de Jesus |
| author_facet | Andréa Magalhães Delfin Gonzalez Miranda Roberval Gonzalez Miranda Maria Ilma Araújo Adriana Almeida de Jesus Angela Silva Luciana B Santana Edward Pearce Edgar M Carvalho Amélia Ribeiro de Jesus |
| author_sort | Andréa Magalhães |
| collection | DOAJ |
| description | This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni. |
| first_indexed | 2024-03-12T18:17:59Z |
| format | Article |
| id | doaj.art-2ceaf919eb3641d588a2016cb0459506 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:17:59Z |
| publishDate | 2004-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-2ceaf919eb3641d588a2016cb04595062023-08-02T09:00:08ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602004-08-0199212610.1590/S0074-02762004000900004Cytokine profile associated with human chronic schistosomiasis mansoniAndréa MagalhãesDelfin Gonzalez MirandaRoberval Gonzalez MirandaMaria Ilma AraújoAdriana Almeida de JesusAngela SilvaLuciana B SantanaEdward PearceEdgar M CarvalhoAmélia Ribeiro de JesusThis study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004schistosomiasishepatic fibrosisinterleukin-5interleukin-13 |
| spellingShingle | Andréa Magalhães Delfin Gonzalez Miranda Roberval Gonzalez Miranda Maria Ilma Araújo Adriana Almeida de Jesus Angela Silva Luciana B Santana Edward Pearce Edgar M Carvalho Amélia Ribeiro de Jesus Cytokine profile associated with human chronic schistosomiasis mansoni Memorias do Instituto Oswaldo Cruz schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
| title | Cytokine profile associated with human chronic schistosomiasis mansoni |
| title_full | Cytokine profile associated with human chronic schistosomiasis mansoni |
| title_fullStr | Cytokine profile associated with human chronic schistosomiasis mansoni |
| title_full_unstemmed | Cytokine profile associated with human chronic schistosomiasis mansoni |
| title_short | Cytokine profile associated with human chronic schistosomiasis mansoni |
| title_sort | cytokine profile associated with human chronic schistosomiasis mansoni |
| topic | schistosomiasis hepatic fibrosis interleukin-5 interleukin-13 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004 |
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