Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to activate β1 integrins, adhere to fibronectin (FN) or...

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Bibliographic Details
Main Authors: Marina Theodosiou, Moritz Widmaier, Ralph T Böttcher, Emanuel Rognoni, Maik Veelders, Mitasha Bharadwaj, Armin Lambacher, Katharina Austen, Daniel J Müller, Roy Zent, Reinhard Fässler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
talin
kindlin
paxillin
integrin
focal adhesion
cell spreading
Online Access:https://elifesciences.org/articles/10130

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