Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs
In the present study, we aimed to evaluate the effects of maternal yeast-based nucleotide (YN) supplementation on the intestinal immune response and barrier function in neonatal pigs, as well as the diarrhoea rate and growth performance in suckling piglets. Sixty-four late-gestation sows were assign...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-03-01
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| Series: | Animal Nutrition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405654520301451 |
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| author | Lumin Gao Chunyan Xie Xiaoxiao Liang Zhihong Li Biao Li Xin Wu Yulong Yin |
| author_facet | Lumin Gao Chunyan Xie Xiaoxiao Liang Zhihong Li Biao Li Xin Wu Yulong Yin |
| author_sort | Lumin Gao |
| collection | DOAJ |
| description | In the present study, we aimed to evaluate the effects of maternal yeast-based nucleotide (YN) supplementation on the intestinal immune response and barrier function in neonatal pigs, as well as the diarrhoea rate and growth performance in suckling piglets. Sixty-four late-gestation sows were assigned to the following groups: the CON (fed a basal diet) and YN groups (fed a basal diet with 4 g YN/kg diet). The experiment started on d 85 of gestation and ended on d 20 of lactation. Diarrhoea rate and average daily gain of the piglets were recorded, and samples of blood and intestines from neonatal piglets were collected before they consumed colostrum during farrowing. Compared with the CON group, maternal YN supplementation increased the weaning weight of litter and decreased the diarrhoea rate (P < 0.01). In addition, maternal YN supplementation promoted the ileal villus development in the neonates compared with that in the CON group (P < 0.01). Maternal YN supplementation also increased the ileal secretory immunoglobulin A (sIgA) level compared with that in the CON group (P < 0.05). The real-time PCR results showed that maternal dietary YN supplementation increased the jejunal and ileal expression of interleukin (IL)-17, IL-8, IL-1β, IL-10 and tumor necrosis factor (TNF)- α in the neonates compared with that in the CON group (P < 0.05). Overall, maternal nucleotide supplementation improved the villus development and innate immunity of neonatal piglets during late pregnancy. This may be associated with the decrease in diarrhoea and the increase in weaning weight of the litter of suckling piglets. |
| first_indexed | 2024-12-14T01:45:21Z |
| format | Article |
| id | doaj.art-2cf383ea01d54908820745bb47e777ba |
| institution | Directory Open Access Journal |
| issn | 2405-6545 |
| language | English |
| last_indexed | 2024-12-14T01:45:21Z |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Animal Nutrition |
| spelling | doaj.art-2cf383ea01d54908820745bb47e777ba2022-12-21T23:21:35ZengKeAi Communications Co., Ltd.Animal Nutrition2405-65452021-03-01718493Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigsLumin Gao0Chunyan Xie1Xiaoxiao Liang2Zhihong Li3Biao Li4Xin Wu5Yulong Yin6Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, ChinaHunan Co-Innovation Center of Safety Animal Production, College of Resources and Environment, Hunan Agricultural University, Changsha 410128, ChinaHenan Zhongke Ground Food Co., Ltd, Zhengzhou 450001, ChinaThe Hubei Provincial Key Laboratory of Yeast Function, Angel Yeast Co., Ltd, Yichang 443003, ChinaThe Hubei Provincial Key Laboratory of Yeast Function, Angel Yeast Co., Ltd, Yichang 443003, ChinaKey Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, China; Hunan Co-Innovation Center of Safety Animal Production, College of Resources and Environment, Hunan Agricultural University, Changsha 410128, China; Institute of Biological Resources, Jiangxi Academy of Sciences, Nanchang 330096, China; Corresponding author.Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan 410125, China; Hunan Co-Innovation Center of Safety Animal Production, College of Resources and Environment, Hunan Agricultural University, Changsha 410128, ChinaIn the present study, we aimed to evaluate the effects of maternal yeast-based nucleotide (YN) supplementation on the intestinal immune response and barrier function in neonatal pigs, as well as the diarrhoea rate and growth performance in suckling piglets. Sixty-four late-gestation sows were assigned to the following groups: the CON (fed a basal diet) and YN groups (fed a basal diet with 4 g YN/kg diet). The experiment started on d 85 of gestation and ended on d 20 of lactation. Diarrhoea rate and average daily gain of the piglets were recorded, and samples of blood and intestines from neonatal piglets were collected before they consumed colostrum during farrowing. Compared with the CON group, maternal YN supplementation increased the weaning weight of litter and decreased the diarrhoea rate (P < 0.01). In addition, maternal YN supplementation promoted the ileal villus development in the neonates compared with that in the CON group (P < 0.01). Maternal YN supplementation also increased the ileal secretory immunoglobulin A (sIgA) level compared with that in the CON group (P < 0.05). The real-time PCR results showed that maternal dietary YN supplementation increased the jejunal and ileal expression of interleukin (IL)-17, IL-8, IL-1β, IL-10 and tumor necrosis factor (TNF)- α in the neonates compared with that in the CON group (P < 0.05). Overall, maternal nucleotide supplementation improved the villus development and innate immunity of neonatal piglets during late pregnancy. This may be associated with the decrease in diarrhoea and the increase in weaning weight of the litter of suckling piglets.http://www.sciencedirect.com/science/article/pii/S2405654520301451NucleotideDiarrhoeaGrowth performanceSowNeonatal piglet |
| spellingShingle | Lumin Gao Chunyan Xie Xiaoxiao Liang Zhihong Li Biao Li Xin Wu Yulong Yin Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs Animal Nutrition Nucleotide Diarrhoea Growth performance Sow Neonatal piglet |
| title | Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| title_full | Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| title_fullStr | Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| title_full_unstemmed | Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| title_short | Yeast-based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| title_sort | yeast based nucleotide supplementation in mother sows modifies the intestinal barrier function and immune response of neonatal pigs |
| topic | Nucleotide Diarrhoea Growth performance Sow Neonatal piglet |
| url | http://www.sciencedirect.com/science/article/pii/S2405654520301451 |
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