Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding
The advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other approaches are emerging. In this discussion, we ex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00335/full |
| _version_ | 1819107502073053184 |
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| author | Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Donald M. Engelman |
| author_facet | Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Donald M. Engelman |
| author_sort | Yana K. Reshetnyak |
| collection | DOAJ |
| description | The advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other approaches are emerging. In this discussion, we examine the use of cell surface acidity as a feature that can be exploited by using pH-sensitive peptide folding to target agents to diseased cell surfaces or cytoplasms. |
| first_indexed | 2024-12-22T02:55:03Z |
| format | Article |
| id | doaj.art-2cf5a66d3d8843e5b5f8a25fe7fc02a2 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-22T02:55:03Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-2cf5a66d3d8843e5b5f8a25fe7fc02a22022-12-21T18:41:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-04-01810.3389/fbioe.2020.00335509182Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide FoldingYana K. Reshetnyak0Anna Moshnikova1Oleg A. Andreev2Donald M. Engelman3Department of Physics, The University of Rhode Island, Kingston, RI, United StatesDepartment of Physics, The University of Rhode Island, Kingston, RI, United StatesDepartment of Physics, The University of Rhode Island, Kingston, RI, United StatesDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, United StatesThe advantages of targeted therapy have motivated many efforts to find distinguishing features between the molecular cell surface landscapes of diseased and normal cells. Typically, the features have been proteins, lipids or carbohydrates, but other approaches are emerging. In this discussion, we examine the use of cell surface acidity as a feature that can be exploited by using pH-sensitive peptide folding to target agents to diseased cell surfaces or cytoplasms.https://www.frontiersin.org/article/10.3389/fbioe.2020.00335/fullcancerinflammationimagingtherapypHLIPfluorescence |
| spellingShingle | Yana K. Reshetnyak Anna Moshnikova Oleg A. Andreev Donald M. Engelman Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding Frontiers in Bioengineering and Biotechnology cancer inflammation imaging therapy pHLIP fluorescence |
| title | Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding |
| title_full | Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding |
| title_fullStr | Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding |
| title_full_unstemmed | Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding |
| title_short | Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding |
| title_sort | targeting acidic diseased tissues by ph triggered membrane associated peptide folding |
| topic | cancer inflammation imaging therapy pHLIP fluorescence |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00335/full |
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