Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom
Abstract Background Multimorbidity is better prevented in younger ages than in older ages. This study aims to identify the differences in comorbidity patterns in middle-aged inpatients from China and the United Kingdom (UK). Methods We utilized 184,133 and 180,497 baseline hospitalization records in...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-023-03204-y |
| _version_ | 1797388251550449664 |
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| author | Yining Bao Pengyi Lu Mengjie Wang Xueli Zhang Aowei Song Xiaoyun Gu Ting Ma Shu Su Lin Wang Xianwen Shang Zhuoting Zhu Yuhang Zhai Mingguang He Zengbin Li Hanting Liu Christopher K. Fairley Jiangcun Yang Lei Zhang |
| author_facet | Yining Bao Pengyi Lu Mengjie Wang Xueli Zhang Aowei Song Xiaoyun Gu Ting Ma Shu Su Lin Wang Xianwen Shang Zhuoting Zhu Yuhang Zhai Mingguang He Zengbin Li Hanting Liu Christopher K. Fairley Jiangcun Yang Lei Zhang |
| author_sort | Yining Bao |
| collection | DOAJ |
| description | Abstract Background Multimorbidity is better prevented in younger ages than in older ages. This study aims to identify the differences in comorbidity patterns in middle-aged inpatients from China and the United Kingdom (UK). Methods We utilized 184,133 and 180,497 baseline hospitalization records in middle-aged populations (40–59 years) from Shaanxi, China, and UK Biobank. Logistic regression was used to calculate odds ratios and P values for 43,110 unique comorbidity patterns in Chinese inpatients and 21,026 unique comorbidity patterns in UK inpatients. We included the statistically significant (P values adjusted by Bonferroni correction) and common comorbidity patterns (the pattern with prevalence > 1/10,000 in each dataset) and employed network analysis to construct multimorbidity networks and compare feature differences in multimorbidity networks for Chinese and UK inpatients, respectively. We defined hub diseases as diseases having the top 10 highest number of unique comorbidity patterns in the multimorbidity network. Results We reported that 57.12% of Chinese inpatients had multimorbidity, substantially higher than 30.39% of UK inpatients. The complete multimorbidity network for Chinese inpatients consisted of 1367 comorbidities of 341 diseases and was 2.93 × more complex than that of 467 comorbidities of 215 diseases in the UK. In males, the complexity of the multimorbidity network in China was 2.69 × more than their UK counterparts, while the ratio was 2.63 × in females. Comorbidities associated with hub diseases represented 68.26% of comorbidity frequencies in the complete multimorbidity network in Chinese inpatients and 55.61% in UK inpatients. Essential hypertension, dyslipidemia, type 2 diabetes mellitus, and gastritis and duodenitis were the hub diseases in both populations. The Chinese inpatients consistently demonstrated a higher frequency of comorbidities related to circulatory and endocrine/nutritional/metabolic diseases. In the UK, aside from these comorbidities, comorbidities related to digestive and genitourinary diseases were also prevalent, particularly the latter among female inpatients. Conclusions Chinese inpatients exhibit higher multimorbidity prevalence and more complex networks compared to their UK counterparts. Multimorbidity with circulatory and endocrine/nutritional/metabolic diseases among both Chinese and UK inpatients necessitates tailored surveillance, prevention, and intervention approaches. Targeted interventions for digestive and genitourinary diseases are warranted for the UK. |
| first_indexed | 2024-03-08T22:38:06Z |
| format | Article |
| id | doaj.art-2cf69efa790c49dda44e041773e2d31c |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-03-08T22:38:06Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-2cf69efa790c49dda44e041773e2d31c2023-12-17T12:20:06ZengBMCBMC Medicine1741-70152023-12-0121111310.1186/s12916-023-03204-yExploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United KingdomYining Bao0Pengyi Lu1Mengjie Wang2Xueli Zhang3Aowei Song4Xiaoyun Gu5Ting Ma6Shu Su7Lin Wang8Xianwen Shang9Zhuoting Zhu10Yuhang Zhai11Mingguang He12Zengbin Li13Hanting Liu14Christopher K. Fairley15Jiangcun Yang16Lei Zhang17China-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterMedical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityDepartment of Transfusion Medicine, Shaanxi Provincial People’s HospitalDepartment of Information Technological, Shaanxi Health Information CenterDepartment of Transfusion Medicine, Shaanxi Provincial People’s HospitalClinical Research Management Office, The Second Affiliated Hospital of ChongQing Medical UniversityAIM Lab, Faculty of IT, Monash UniversityRoyal Melbourne Hospital, University of MelbourneCentre for Eye Research Australia, Royal Victorian Eye and Ear HospitalGies College of Business, University of Illinois Urbana-ChampaignCentre for Eye Research Australia, Royal Victorian Eye and Ear HospitalChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterMelbourne Sexual Health Centre, Alfred HealthDepartment of Transfusion Medicine, Shaanxi Provincial People’s HospitalChina-Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi’an Jiaotong University Health Science CenterAbstract Background Multimorbidity is better prevented in younger ages than in older ages. This study aims to identify the differences in comorbidity patterns in middle-aged inpatients from China and the United Kingdom (UK). Methods We utilized 184,133 and 180,497 baseline hospitalization records in middle-aged populations (40–59 years) from Shaanxi, China, and UK Biobank. Logistic regression was used to calculate odds ratios and P values for 43,110 unique comorbidity patterns in Chinese inpatients and 21,026 unique comorbidity patterns in UK inpatients. We included the statistically significant (P values adjusted by Bonferroni correction) and common comorbidity patterns (the pattern with prevalence > 1/10,000 in each dataset) and employed network analysis to construct multimorbidity networks and compare feature differences in multimorbidity networks for Chinese and UK inpatients, respectively. We defined hub diseases as diseases having the top 10 highest number of unique comorbidity patterns in the multimorbidity network. Results We reported that 57.12% of Chinese inpatients had multimorbidity, substantially higher than 30.39% of UK inpatients. The complete multimorbidity network for Chinese inpatients consisted of 1367 comorbidities of 341 diseases and was 2.93 × more complex than that of 467 comorbidities of 215 diseases in the UK. In males, the complexity of the multimorbidity network in China was 2.69 × more than their UK counterparts, while the ratio was 2.63 × in females. Comorbidities associated with hub diseases represented 68.26% of comorbidity frequencies in the complete multimorbidity network in Chinese inpatients and 55.61% in UK inpatients. Essential hypertension, dyslipidemia, type 2 diabetes mellitus, and gastritis and duodenitis were the hub diseases in both populations. The Chinese inpatients consistently demonstrated a higher frequency of comorbidities related to circulatory and endocrine/nutritional/metabolic diseases. In the UK, aside from these comorbidities, comorbidities related to digestive and genitourinary diseases were also prevalent, particularly the latter among female inpatients. Conclusions Chinese inpatients exhibit higher multimorbidity prevalence and more complex networks compared to their UK counterparts. Multimorbidity with circulatory and endocrine/nutritional/metabolic diseases among both Chinese and UK inpatients necessitates tailored surveillance, prevention, and intervention approaches. Targeted interventions for digestive and genitourinary diseases are warranted for the UK.https://doi.org/10.1186/s12916-023-03204-yMultimorbidityComorbidityNetwork analysisMiddle-agedInpatientsChina |
| spellingShingle | Yining Bao Pengyi Lu Mengjie Wang Xueli Zhang Aowei Song Xiaoyun Gu Ting Ma Shu Su Lin Wang Xianwen Shang Zhuoting Zhu Yuhang Zhai Mingguang He Zengbin Li Hanting Liu Christopher K. Fairley Jiangcun Yang Lei Zhang Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom BMC Medicine Multimorbidity Comorbidity Network analysis Middle-aged Inpatients China |
| title | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom |
| title_full | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom |
| title_fullStr | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom |
| title_full_unstemmed | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom |
| title_short | Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom |
| title_sort | exploring multimorbidity profiles in middle aged inpatients a network based comparative study of china and the united kingdom |
| topic | Multimorbidity Comorbidity Network analysis Middle-aged Inpatients China |
| url | https://doi.org/10.1186/s12916-023-03204-y |
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