Activity of Meropenem and Ciprofloxacin in vitro Against Oxacillin Resistant Staphylococcus aureus
A total of 150 clinical specimens were collected from patients attending Medical city Hospital in Baghdad to isolation and identification Staphylococcus aureus on species level by Api staph 20 system (Biomereux , france). 33 (22%) isolates were isolated from Staphylococcus aureus, this isolates div...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2010-12-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/339 |
| Summary: | A total of 150 clinical specimens were collected from patients attending Medical city Hospital in Baghdad to isolation and identification Staphylococcus aureus on species level by Api staph 20 system (Biomereux , france). 33 (22%) isolates were isolated from Staphylococcus aureus, this isolates divided according to source of isolate: 15 (37.5%) isolate from wounds, 10 (20%) isolate from bone infection, 7 (50%) isolate from nasal and throat swabs, one (2%) isolate from urine.
Thirteen antibiotics were used for sensitivity test; all isolate were resistance to Pencillin (100%), Ampicillin (100%), and while Erythromycin (75.8%). Among the various antimicrobial Oxacillin showed high resisance (69.6%), most effective antibiotics on S. aureus were Vancomycin (100%), Meropenem (100%), while Amikacin and Ciprofloxacin in Percentage 79%, 76% recpectively.
In vitro minimum inhibitory concentration (MIC) of Meropenem and Ciprofloxacin were done to determined inhibition effect against all isolates of S.
aureus Which is resist to Oxacillin( 23 isolate ) in Serial concentration (4-1024) μg / ml, S. aureus was resistant to Meropenem in percentage 70% in break point
≥ 16, while Ciprofloxacim was resistant in percentage 74% in berak point ≥4.
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| ISSN: | 1815-0993 2959-183X |