IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma
Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-1...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2022-05-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/13444.pdf |
| _version_ | 1797425594664747008 |
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| author | Siti Muhamad Nur Husna Norasnieda Md Shukri Noor Suryani Mohd Ashari Kah Keng Wong |
| author_facet | Siti Muhamad Nur Husna Norasnieda Md Shukri Noor Suryani Mohd Ashari Kah Keng Wong |
| author_sort | Siti Muhamad Nur Husna |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-13 axis at various levels of its signaling pathway has emerged as promising targeted therapy in both AR and asthma patient populations. In this review, we discuss the biological characteristics of IL-4 and IL-13, their signaling pathways, and therapeutic antibodies against each cytokine as well as their receptors. In particular, the pleiotropic roles of IL-4 and IL-13 in orchestrating Th2 responses in AR and asthma patients indicate that dual IL-4/IL-13 blockade is a promising therapeutic strategy for both diseases. |
| first_indexed | 2024-03-09T08:17:25Z |
| format | Article |
| id | doaj.art-2cfecb4395d54d58bd5af5cdf73ddd9d |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:17:25Z |
| publishDate | 2022-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-2cfecb4395d54d58bd5af5cdf73ddd9d2023-12-02T21:58:55ZengPeerJ Inc.PeerJ2167-83592022-05-0110e1344410.7717/peerj.13444IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthmaSiti Muhamad Nur Husna0Norasnieda Md Shukri1Noor Suryani Mohd Ashari2Kah Keng Wong3Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaDepartment of Otorhinolaryngology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaDepartment of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaAllergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-13 axis at various levels of its signaling pathway has emerged as promising targeted therapy in both AR and asthma patient populations. In this review, we discuss the biological characteristics of IL-4 and IL-13, their signaling pathways, and therapeutic antibodies against each cytokine as well as their receptors. In particular, the pleiotropic roles of IL-4 and IL-13 in orchestrating Th2 responses in AR and asthma patients indicate that dual IL-4/IL-13 blockade is a promising therapeutic strategy for both diseases.https://peerj.com/articles/13444.pdfIL-4IL-13IL-4RαIL-13Rα1Allergic rhinitisAsthma |
| spellingShingle | Siti Muhamad Nur Husna Norasnieda Md Shukri Noor Suryani Mohd Ashari Kah Keng Wong IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma PeerJ IL-4 IL-13 IL-4Rα IL-13Rα1 Allergic rhinitis Asthma |
| title | IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma |
| title_full | IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma |
| title_fullStr | IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma |
| title_full_unstemmed | IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma |
| title_short | IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma |
| title_sort | il 4 il 13 axis as therapeutic targets in allergic rhinitis and asthma |
| topic | IL-4 IL-13 IL-4Rα IL-13Rα1 Allergic rhinitis Asthma |
| url | https://peerj.com/articles/13444.pdf |
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