Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study
An essential metric for determining the efficacy of tuberculosis (TB) control programs is the evaluation of TB treatment outcomes; this study was conducted to investigate treatment outcomes and associated factors among tuberculosis patients in rural areas of Eastern Cape, South Africa. Assessing tre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/6/315 |
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| author | Lindiwe M. Faye Mojisola C. Hosu Joshua Iruedo Sandeep Vasaikar Kolisa A. Nokoyo Urgent Tsuro Teke Apalata |
| author_facet | Lindiwe M. Faye Mojisola C. Hosu Joshua Iruedo Sandeep Vasaikar Kolisa A. Nokoyo Urgent Tsuro Teke Apalata |
| author_sort | Lindiwe M. Faye |
| collection | DOAJ |
| description | An essential metric for determining the efficacy of tuberculosis (TB) control programs is the evaluation of TB treatment outcomes; this study was conducted to investigate treatment outcomes and associated factors among tuberculosis patients in rural areas of Eastern Cape, South Africa. Assessing treatment outcomes is fundamental to facilitating the End TB Strategy’s set target. Clinic records from 457 patients with DR-TB were examined for data collection while 101 patients were followed up prospectively. Data were analyzed using Stata version 17.0. The odds ratio and 95% confidence interval were calculated to check the association between variables. <i>p</i> ≤ 0.05 was considered statistically significant. Of the 427 participants, 65.8% had successful treatment whilst 34.2% had unsuccessful TB treatment. A total of 61.2% and 39% of the HIV-positive and HIV-negative participants had a successful TB treatment whilst 66% and 34% of both HIV-negative and positive participants had unsuccessful TB treatment. From the 101 patients that were followed up, smokers took longer to have treatment outcomes compared to non-smokers. In the study with HIV/TB co-infection, men predominated. HIV and tuberculosis co-infection made therapy difficult with unfavorable effects on TB management. The treatment success rate (65.8%) was lower than the WHO threshold standard with a high proportion of patients being lost to the follow up. The co-infection of tuberculosis and HIV resulted in undesirable treatment outcomes. Strengthening TB surveillance and control is recommended. |
| first_indexed | 2024-03-11T01:50:47Z |
| format | Article |
| id | doaj.art-2d01aca5cdc542c7b00d68f01b686638 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-11T01:50:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-2d01aca5cdc542c7b00d68f01b6866382023-11-18T12:56:27ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-06-018631510.3390/tropicalmed8060315Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional StudyLindiwe M. Faye0Mojisola C. Hosu1Joshua Iruedo2Sandeep Vasaikar3Kolisa A. Nokoyo4Urgent Tsuro5Teke Apalata6Department of Laboratory Medicine and Pathology, Walter Sisulu University and National Health Laboratory Services (NHLS), Private Bag X5117, Mthatha 5099, South AfricaDepartment of Laboratory Medicine and Pathology, Walter Sisulu University and National Health Laboratory Services (NHLS), Private Bag X5117, Mthatha 5099, South AfricaDepartment of Family Medicine, Walter Sisulu University, Private Bag X5117, Mthatha 5099, South AfricaDepartment of Laboratory Medicine and Pathology, Walter Sisulu University and National Health Laboratory Services (NHLS), Private Bag X5117, Mthatha 5099, South AfricaWits School of Public Health, 27 St Andrew Road, Parktown, Johannesburg 2193, South AfricaDepartment of Public Health, Walter Sisulu University, Private Bag X5117, Mthatha 5099, South AfricaDepartment of Laboratory Medicine and Pathology, Walter Sisulu University and National Health Laboratory Services (NHLS), Private Bag X5117, Mthatha 5099, South AfricaAn essential metric for determining the efficacy of tuberculosis (TB) control programs is the evaluation of TB treatment outcomes; this study was conducted to investigate treatment outcomes and associated factors among tuberculosis patients in rural areas of Eastern Cape, South Africa. Assessing treatment outcomes is fundamental to facilitating the End TB Strategy’s set target. Clinic records from 457 patients with DR-TB were examined for data collection while 101 patients were followed up prospectively. Data were analyzed using Stata version 17.0. The odds ratio and 95% confidence interval were calculated to check the association between variables. <i>p</i> ≤ 0.05 was considered statistically significant. Of the 427 participants, 65.8% had successful treatment whilst 34.2% had unsuccessful TB treatment. A total of 61.2% and 39% of the HIV-positive and HIV-negative participants had a successful TB treatment whilst 66% and 34% of both HIV-negative and positive participants had unsuccessful TB treatment. From the 101 patients that were followed up, smokers took longer to have treatment outcomes compared to non-smokers. In the study with HIV/TB co-infection, men predominated. HIV and tuberculosis co-infection made therapy difficult with unfavorable effects on TB management. The treatment success rate (65.8%) was lower than the WHO threshold standard with a high proportion of patients being lost to the follow up. The co-infection of tuberculosis and HIV resulted in undesirable treatment outcomes. Strengthening TB surveillance and control is recommended.https://www.mdpi.com/2414-6366/8/6/315treatment outcomesDR-TBMDR-TBTB-HIV co-infectiontreatment success rate |
| spellingShingle | Lindiwe M. Faye Mojisola C. Hosu Joshua Iruedo Sandeep Vasaikar Kolisa A. Nokoyo Urgent Tsuro Teke Apalata Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study Tropical Medicine and Infectious Disease treatment outcomes DR-TB MDR-TB TB-HIV co-infection treatment success rate |
| title | Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study |
| title_full | Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study |
| title_fullStr | Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study |
| title_full_unstemmed | Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study |
| title_short | Treatment Outcomes and Associated Factors among Tuberculosis Patients from Selected Rural Eastern Cape Hospitals: An Ambidirectional Study |
| title_sort | treatment outcomes and associated factors among tuberculosis patients from selected rural eastern cape hospitals an ambidirectional study |
| topic | treatment outcomes DR-TB MDR-TB TB-HIV co-infection treatment success rate |
| url | https://www.mdpi.com/2414-6366/8/6/315 |
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