Anaplastic meningioma: The dark side of meningiomas
Anaplastic meningioma is a rare malignant tumor of the meninges, with a very aggressive behavior and a grim prognosis. Here we report a case of a 64-year old man which presented to the neurosurgery department with motor deficit in the right hemi–body, loss of speech and disorientation. Magnetic re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Victor Babes University of Medicine and Pharmacy Timisoara
2017-06-01
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| Series: | Research and Clinical Medicine |
| Subjects: | |
| Online Access: | http://www.resclinmed.eu/public/data_files/articles/20/article_20.pdf |
| _version_ | 1819044574838915072 |
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| author | Andreea Cioca Fit Ana-Maria Irina Marin |
| author_facet | Andreea Cioca Fit Ana-Maria Irina Marin |
| author_sort | Andreea Cioca |
| collection | DOAJ |
| description | Anaplastic meningioma is a rare malignant tumor of the meninges, with a very aggressive behavior and a grim prognosis. Here we
report a case of a 64-year old man which presented to the neurosurgery department with motor deficit in the right hemi–body, loss
of speech and disorientation. Magnetic resonance imaging detected a mass located in the left frontal lobe that measured 7/8/7 cm,
leading to the conclusion that surgery is necessary. Microscopic examination of the tumor showed great number of hypercellular areas
with a high mitotic index, and focal necrosis with psammoma bodies. Using a panel of antibodies such as EMA, vimentin, CD34 GFAP,
pancytokeratin and Ki67, we concluded that he final diagnosis was anaplastic meningioma, WHO grade III. Due to its morphological
similarity with other tumors, the diagnosis of anaplastic meningioma may be challenging. |
| first_indexed | 2024-12-21T10:14:51Z |
| format | Article |
| id | doaj.art-2d01d44a8e3848dfa4cc82b2b992f11c |
| institution | Directory Open Access Journal |
| issn | 2360-1124 2537-5393 |
| language | English |
| last_indexed | 2024-12-21T10:14:51Z |
| publishDate | 2017-06-01 |
| publisher | Victor Babes University of Medicine and Pharmacy Timisoara |
| record_format | Article |
| series | Research and Clinical Medicine |
| spelling | doaj.art-2d01d44a8e3848dfa4cc82b2b992f11c2022-12-21T19:07:36ZengVictor Babes University of Medicine and Pharmacy TimisoaraResearch and Clinical Medicine2360-11242537-53932017-06-01I21315Anaplastic meningioma: The dark side of meningiomasAndreea Cioca0 Fit Ana-Maria 1 Irina Marin2Angiogenesis Research Center, “Victor Babes” University of Medicine and Pharmacy, TimisoaraDepartment of Pathology, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor", Cluj-NapocaDepartment of Pathology, Sheba Medical Center, Tel-Hashomer, IsraelAnaplastic meningioma is a rare malignant tumor of the meninges, with a very aggressive behavior and a grim prognosis. Here we report a case of a 64-year old man which presented to the neurosurgery department with motor deficit in the right hemi–body, loss of speech and disorientation. Magnetic resonance imaging detected a mass located in the left frontal lobe that measured 7/8/7 cm, leading to the conclusion that surgery is necessary. Microscopic examination of the tumor showed great number of hypercellular areas with a high mitotic index, and focal necrosis with psammoma bodies. Using a panel of antibodies such as EMA, vimentin, CD34 GFAP, pancytokeratin and Ki67, we concluded that he final diagnosis was anaplastic meningioma, WHO grade III. Due to its morphological similarity with other tumors, the diagnosis of anaplastic meningioma may be challenging.http://www.resclinmed.eu/public/data_files/articles/20/article_20.pdfanaplastic meningiomadifferential diagnosisimmunohistochemistry |
| spellingShingle | Andreea Cioca Fit Ana-Maria Irina Marin Anaplastic meningioma: The dark side of meningiomas Research and Clinical Medicine anaplastic meningioma differential diagnosis immunohistochemistry |
| title | Anaplastic meningioma: The dark side of meningiomas |
| title_full | Anaplastic meningioma: The dark side of meningiomas |
| title_fullStr | Anaplastic meningioma: The dark side of meningiomas |
| title_full_unstemmed | Anaplastic meningioma: The dark side of meningiomas |
| title_short | Anaplastic meningioma: The dark side of meningiomas |
| title_sort | anaplastic meningioma the dark side of meningiomas |
| topic | anaplastic meningioma differential diagnosis immunohistochemistry |
| url | http://www.resclinmed.eu/public/data_files/articles/20/article_20.pdf |
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