Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matche...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2020-05-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/1948 |
| _version_ | 1797197867204476928 |
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| author | A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina |
| author_facet | A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina |
| author_sort | A. V. Shabaldin |
| collection | DOAJ |
| description | Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537*G/G – rs3804277*T/T (OR = 8.26) and three-locus model rs2234246*C/T – rs1817537*C/G – rs7768162*A/G (OR = 13.76). The two-locus model rs1817537*С/С – rs3804277*T/T (OR = 0.03) and three-locus model rs2234246*T/T – rs1817537*C/C – rs7768162*G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies. |
| first_indexed | 2024-03-08T05:48:29Z |
| format | Article |
| id | doaj.art-2d01fd644e024a168193648d6c287b7d |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:50:47Z |
| publishDate | 2020-05-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-2d01fd644e024a168193648d6c287b7d2024-04-22T13:07:45ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2020-05-0122350551810.15789/1563-0625-AOP-19481282Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomaliesA. V. Shabaldin0A. V. Tsepokina1S. A. Shmulevich2N. S. Deeva3A. V. Ponasenko4L. V. Antonova5E. V. Shabaldina6Research Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo L. Barbarash Cardiological DispensaryResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesKemerovo State Medical UniversityEight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537*G/G – rs3804277*T/T (OR = 8.26) and three-locus model rs2234246*C/T – rs1817537*C/G – rs7768162*A/G (OR = 13.76). The two-locus model rs1817537*С/С – rs3804277*T/T (OR = 0.03) and three-locus model rs2234246*T/T – rs1817537*C/C – rs7768162*G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies.https://www.mimmun.ru/mimmun/article/view/1948trem-1congenital heart defectsgenetic polymorphisminter-locus interactions |
| spellingShingle | A. V. Shabaldin A. V. Tsepokina S. A. Shmulevich N. S. Deeva A. V. Ponasenko L. V. Antonova E. V. Shabaldina Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies Медицинская иммунология trem-1 congenital heart defects genetic polymorphism inter-locus interactions |
| title | Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies |
| title_full | Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies |
| title_fullStr | Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies |
| title_full_unstemmed | Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies |
| title_short | Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies |
| title_sort | association of polymorphisms the trigger receptor gene expressed by myeloid cells i trem 1 i in sporadic congenital heart defects without chromosome anomalies |
| topic | trem-1 congenital heart defects genetic polymorphism inter-locus interactions |
| url | https://www.mimmun.ru/mimmun/article/view/1948 |
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