Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype
Background and aims: Exposure to environmental nanoparticles is related to the adverse impact on health, including cardiovascular system. Various forms of nanoparticles have been reported to interact with endothelium and induce inflammation. However, the potential role of nanoparticles in the pathog...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321012240 |
| _version_ | 1798025624270405632 |
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| author | Kamila Stachyra Anna Wiśniewska Anna Kiepura Katarzyna Kuś Filip Rolski Klaudia Czepiel Łukasz Chmura Grzegorz Majka Marcin Surmiak Justyna Polaczek Rudi van Eldik Maciej Suski Rafał Olszanecki |
| author_facet | Kamila Stachyra Anna Wiśniewska Anna Kiepura Katarzyna Kuś Filip Rolski Klaudia Czepiel Łukasz Chmura Grzegorz Majka Marcin Surmiak Justyna Polaczek Rudi van Eldik Maciej Suski Rafał Olszanecki |
| author_sort | Kamila Stachyra |
| collection | DOAJ |
| description | Background and aims: Exposure to environmental nanoparticles is related to the adverse impact on health, including cardiovascular system. Various forms of nanoparticles have been reported to interact with endothelium and induce inflammation. However, the potential role of nanoparticles in the pathogenesis of atherosclerosis and their mechanisms of action are still unclear. The aim of this study was to investigate the effect of two broadly used nanomaterials, which also occur in natural environment - silicon oxide (SiO2) and ferric oxide (Fe2O3) in the form of nanoparticles (NPs) - on the development of atherosclerosis. Methods: We used apolipoprotein E-knockout mice exposed to silica and ferric oxide nanoparticles in a whole body inhalation chamber. Results: Inhaled silica nanoparticles augmented the atherosclerotic lesions and increased the percentage of pro-inflammatory M1 macrophages in both the plaque and the peritoneum in apoE-/- mice. Exposure to ferric oxide nanoparticles did not enhance atherogenesis process, however, it caused significant changes in the atherosclerotic plaque composition (elevated content of CD68-positive macrophages and enlarged necrotic core accompanied by the decreased level of M1 macrophages). Both silica and ferric oxide NPs altered the phenotype of T lymphocytes in the spleen by promoting polarization towards Th17 cells. Conclusions: Exposure to silica and ferric oxide nanoparticles exerts impact on atherosclerosis development and plaque composition. Pro-atherogenic abilities of silica nanoparticles are associated with activation of pro-inflammatory macrophages. |
| first_indexed | 2024-04-11T18:21:51Z |
| format | Article |
| id | doaj.art-2d026d2da83942cb91ccc08f82c77b90 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-11T18:21:51Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-2d026d2da83942cb91ccc08f82c77b902022-12-22T04:09:44ZengElsevierEcotoxicology and Environmental Safety0147-65132022-01-01230113112Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotypeKamila Stachyra0Anna Wiśniewska1Anna Kiepura2Katarzyna Kuś3Filip Rolski4Klaudia Czepiel5Łukasz Chmura6Grzegorz Majka7Marcin Surmiak8Justyna Polaczek9Rudi van Eldik10Maciej Suski11Rafał Olszanecki12Chair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandDepartment of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, 265 Wielicka Street, 30-663 Krakow, PolandChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Immunology, Faculty of Medicine, Jagiellonian University Medical College, 18 Czysta Street, 31-121 Krakow, PolandDepartment of Internal Medicine, Jagiellonian University Medical College, 8 Skawinska Street, 31-066 Krakow, PolandFaculty of Chemistry, Jagiellonian University, 2 Gronostajowa Street, 30-387 Krakow, PolandFaculty of Chemistry, Jagiellonian University, 2 Gronostajowa Street, 30-387 Krakow, Poland; Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstrasse 1, 91058 Erlangen, GermanyChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, PolandChair of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Krakow, Poland; Corresponding author.Background and aims: Exposure to environmental nanoparticles is related to the adverse impact on health, including cardiovascular system. Various forms of nanoparticles have been reported to interact with endothelium and induce inflammation. However, the potential role of nanoparticles in the pathogenesis of atherosclerosis and their mechanisms of action are still unclear. The aim of this study was to investigate the effect of two broadly used nanomaterials, which also occur in natural environment - silicon oxide (SiO2) and ferric oxide (Fe2O3) in the form of nanoparticles (NPs) - on the development of atherosclerosis. Methods: We used apolipoprotein E-knockout mice exposed to silica and ferric oxide nanoparticles in a whole body inhalation chamber. Results: Inhaled silica nanoparticles augmented the atherosclerotic lesions and increased the percentage of pro-inflammatory M1 macrophages in both the plaque and the peritoneum in apoE-/- mice. Exposure to ferric oxide nanoparticles did not enhance atherogenesis process, however, it caused significant changes in the atherosclerotic plaque composition (elevated content of CD68-positive macrophages and enlarged necrotic core accompanied by the decreased level of M1 macrophages). Both silica and ferric oxide NPs altered the phenotype of T lymphocytes in the spleen by promoting polarization towards Th17 cells. Conclusions: Exposure to silica and ferric oxide nanoparticles exerts impact on atherosclerosis development and plaque composition. Pro-atherogenic abilities of silica nanoparticles are associated with activation of pro-inflammatory macrophages.http://www.sciencedirect.com/science/article/pii/S0147651321012240AtherosclerosisNanoparticlesAtherosclerotic plaqueApoE-knockout miceMacrophages |
| spellingShingle | Kamila Stachyra Anna Wiśniewska Anna Kiepura Katarzyna Kuś Filip Rolski Klaudia Czepiel Łukasz Chmura Grzegorz Majka Marcin Surmiak Justyna Polaczek Rudi van Eldik Maciej Suski Rafał Olszanecki Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype Ecotoxicology and Environmental Safety Atherosclerosis Nanoparticles Atherosclerotic plaque ApoE-knockout mice Macrophages |
| title | Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype |
| title_full | Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype |
| title_fullStr | Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype |
| title_full_unstemmed | Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype |
| title_short | Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype |
| title_sort | inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards m1 phenotype |
| topic | Atherosclerosis Nanoparticles Atherosclerotic plaque ApoE-knockout mice Macrophages |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321012240 |
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