Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report
A 67-year-old man presented to the hospital with complaints of fever and cough. He had a past medical history of renal cell carcinoma and had just started treatment with temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor. A 1-week course of antibiotics did not have any effect on his symp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971218300341 |
| _version_ | 1819294227299827712 |
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| author | Yuki Iijima Namiko Fujioka Yoshinori Uchida Yoichi Kobayashi Toshiharu Tsutsui Yumiko Kakizaki Yoshihiro Miyashita |
| author_facet | Yuki Iijima Namiko Fujioka Yoshinori Uchida Yoichi Kobayashi Toshiharu Tsutsui Yumiko Kakizaki Yoshihiro Miyashita |
| author_sort | Yuki Iijima |
| collection | DOAJ |
| description | A 67-year-old man presented to the hospital with complaints of fever and cough. He had a past medical history of renal cell carcinoma and had just started treatment with temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor. A 1-week course of antibiotics did not have any effect on his symptoms. A chest computed tomography (CT) scan showed the reversed halo sign (RHS). Organizing pneumonia induced by mTOR inhibitor treatment was initially considered. However, transbronchial biopsy revealed clusters of fungal organisms, suggesting infection with Aspergillus spp. Within just 2 weeks, a CT scan showed drastic enlargement of the cavitary lesion, with multiple newly formed consolidations. The patient was diagnosed with invasive pulmonary aspergillosis. Concomitant treatment with voriconazole and micafungin was started. Two weeks after the initiation of treatment, he became afebrile with gradual regression of the cavitary lesion and consolidations. Keywords: mTOR inhibitor, Organizing pneumonia, Reversed halo sign, Invasive pulmonary aspergillosis, Immunocompromise |
| first_indexed | 2024-12-24T04:22:58Z |
| format | Article |
| id | doaj.art-2d034c10e3684bb598184a3539bed404 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-24T04:22:58Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-2d034c10e3684bb598184a3539bed4042022-12-21T17:15:43ZengElsevierInternational Journal of Infectious Diseases1201-97122018-04-01697577Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case reportYuki Iijima0Namiko Fujioka1Yoshinori Uchida2Yoichi Kobayashi3Toshiharu Tsutsui4Yumiko Kakizaki5Yoshihiro Miyashita6Corresponding author.; Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanLung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu City, Yamanashi 400-8506, JapanA 67-year-old man presented to the hospital with complaints of fever and cough. He had a past medical history of renal cell carcinoma and had just started treatment with temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor. A 1-week course of antibiotics did not have any effect on his symptoms. A chest computed tomography (CT) scan showed the reversed halo sign (RHS). Organizing pneumonia induced by mTOR inhibitor treatment was initially considered. However, transbronchial biopsy revealed clusters of fungal organisms, suggesting infection with Aspergillus spp. Within just 2 weeks, a CT scan showed drastic enlargement of the cavitary lesion, with multiple newly formed consolidations. The patient was diagnosed with invasive pulmonary aspergillosis. Concomitant treatment with voriconazole and micafungin was started. Two weeks after the initiation of treatment, he became afebrile with gradual regression of the cavitary lesion and consolidations. Keywords: mTOR inhibitor, Organizing pneumonia, Reversed halo sign, Invasive pulmonary aspergillosis, Immunocompromisehttp://www.sciencedirect.com/science/article/pii/S1201971218300341 |
| spellingShingle | Yuki Iijima Namiko Fujioka Yoshinori Uchida Yoichi Kobayashi Toshiharu Tsutsui Yumiko Kakizaki Yoshihiro Miyashita Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report International Journal of Infectious Diseases |
| title | Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report |
| title_full | Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report |
| title_fullStr | Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report |
| title_full_unstemmed | Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report |
| title_short | Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report |
| title_sort | invasive pulmonary aspergillosis mimicking organizing pneumonia after mtor inhibitor therapy a case report |
| url | http://www.sciencedirect.com/science/article/pii/S1201971218300341 |
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