Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

Mitochondria are supposed to be involved in the early pathogenesis of general anesthesia (GA)-induced neurotoxicity and long-term cognitive deficits in developing brains. However, effective pharmacologic agents targeted on mitochondria during GA exposure are lacking. This study explores the protecti...

Full description

Bibliographic Details
Main Authors:	Jian-Jun Yang, Kuanyu Li, Jing Wu, Shuangying Hao, Xiao-Ru Sun, Hui Zhang, Huihui Li, Hongting Zhao, Mu-Huo Ji
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-04-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	elamipretide general anesthesia antioxidant mitochondrial morphology cognition
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00119/full

Similar Items

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
by: Weixing Zhao, et al.
Published: (2019-11-01)

Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats
by: Yang Liu, et al.
Published: (2021-03-01)

Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice
by: Youmei Zuo, et al.
Published: (2020-08-01)

Use of Elamipretide in patients assigned treatment in the compassionate use program: Case series in pediatric patients with rare orphan diseases
by: Mary Kay Koenig, et al.
Published: (2023-01-01)

Natural history comparison study to assess the efficacy of elamipretide in patients with Barth syndrome
by: Brittany Hornby, et al.
Published: (2022-09-01)

Phase 1 Clinical Trial of Elamipretide in Intermediate Age-Related Macular Degeneration and High-Risk Drusen
by: Michael J. Allingham, MD, PhD, et al.
Published: (2022-03-01)

Phase 1 Clinical Trial of Elamipretide in Dry Age-Related Macular Degeneration and Noncentral Geographic Atrophy
by: Priyatham S. Mettu, MD, et al.
Published: (2022-03-01)

Novel Short-Chain Quinones to Treat Vision Loss in a Rat Model of Diabetic Retinopathy
by: Abraham Daniel, et al.
Published: (2021-01-01)

Elamipretide(SS-31) Attenuates Idiopathic Pulmonary Fibrosis by Inhibiting the Nrf2-Dependent NLRP3 Inflammasome in Macrophages
by: Yunjuan Nie, et al.
Published: (2023-11-01)

Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells
by: Shuangying Hao, et al.
Published: (2015-12-01)

Anesthetic Considerations in Patients with Mitochondrial Disorders
by: Ziske Maritska, et al.
Published: (2023-07-01)

Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.
by: Meng Zhang, et al.
Published: (2017-01-01)

Clinical Evalualtion in Isoflurane and Sevoflurane Anesthesia in Rat
by: Flavia Ruxanda, et al.
Published: (2016-07-01)

Anesthetic protocol using propofol and isoflurane in spectacled bear (Tremarctos ornatus)
by: Júlio Rodrigues Pereira Júnior, et al.
Published: (2023-12-01)

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice
by: Yunxia Fan, et al.
Published: (2018-11-01)

Cur@SF NPs alleviate Friedreich’s ataxia in a mouse model through synergistic iron chelation and antioxidation
by: Li Xu, et al.
Published: (2022-03-01)

Lidocaine constant rate infusion in isoflurane anesthetized neonatal foals
by: Carlotta Lambertini, et al.
Published: (2024-01-01)

Deficiency of Mitochondrial Functions and Peroxidation of Frontoparietal Cortex Enhance Isoflurane Sensitivity in Aging Mice
by: Cansheng Gong, et al.
Published: (2020-12-01)

SS31 Alleviates Pressure Overload-Induced Heart Failure Caused by Sirt3-Mediated Mitochondrial Fusion
by: Mengying Suo, et al.
Published: (2022-05-01)

The effects of general anesthetics on mitochondrial structure and function in the developing brain
by: Kaley Hogarth, et al.
Published: (2023-07-01)

Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl–Lidocaine–Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy
by: Perla I. Velázquez-Delgado, et al.
Published: (2021-02-01)

Association Between Burst-Suppression Latency and Burst-Suppression Ratio Under Isoflurane or Adjuvant Drugs With Isoflurane Anesthesia in Mice
by: Di Wang, et al.
Published: (2021-09-01)

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs
by: Fabricio de Oliveira Frazilio, et al.
Published: (2014-01-01)

Regional anesthesia in two consecutive surgeries in a patient with mitochondrial neurogastrointestinal encephalomyopathy: a case report
by: Tayfun Sugur, et al.
Published: (2021-01-01)

Anesthesia for bariatric surgery in patient with mitochondrial myopathy – case report
by: Carlos Eduardo Coimbra Melonio, et al.
Published: (2021-01-01)

Comparison of the Use of Mask or Chamber in Inducing Anesthesia with Isoflurane in Rabbits
by: Navid Salmanzadeh, et al.
Published: (2008-03-01)

Comparison of Propofol and Isoflurane Effect on Hemorrhage during Spine Surgery
by: Behrooz Karkhanehie, et al.
Published: (2015-03-01)

Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats
by: Hangbin Chen, et al.
Published: (2023-02-01)

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop
by: Zhengming Shan, et al.
Published: (2023-06-01)

Effects of inspired oxygen fractions in rabbits anesthetized with isoflurane or sevoflurane, maintained on spontaneous ventilation
by: M. Horr, et al.

Application of quinpirole in the paraventricular thalamus facilitates emergence from isoflurane anesthesia in mice
by: Yawen Ao, et al.
Published: (2021-01-01)

Anesthetic considerations of Joubert syndrome in patients with mitochondrial disease - A case report -
by: Jeong Yeon Kim, et al.
Published: (2021-04-01)

Evaluation of effect of entropy monitoring on isoflurane consumption and recovery from anesthesia
by: Kush Ashokkumar Goyal, et al.
Published: (2017-01-01)

Isoflurane exposure in infant rats acutely increases aquaporin 4 and does not cause neurocognitive impairment
by: Serdar Demirgan, et al.
Published: (2019-08-01)

Activating ryanodine receptor improves isoflurane-induced cognitive dysfunction
by: Binwen Liu, et al.
Published: (2023-11-01)

Parabrachial nucleus astrocytes regulate wakefulness and isoflurane anesthesia in mice
by: Pei-Chang Liu, et al.
Published: (2023-01-01)

Isoflurane Anesthesia’s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model
by: Yana Y. Shpetko, et al.
Published: (2023-07-01)

Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery
by: Jialing Lin, et al.
Published: (2023-06-01)

Protective effect of isoflurane preconditioning on neurological function in rats with HIE
by: Yi Fei‐Sun, et al.
Published: (2022-12-01)

Basal Forebrain Cholinergic Activity Modulates Isoflurane and Propofol Anesthesia
by: Tian-Yuan Luo, et al.
Published: (2020-10-01)