Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age
Metabolic bone disease (MBD) predominantly affects preterm infants, particularly very-low-birth-weight (VLBW) infants weighing <1500 g. However, there are limited reports on MBD and neurodevelopmental outcomes. This study aimed to analyze the risk factors for MBD and understand its impact on neur...
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2227-9067/11/1/76 |
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| author | Yu-Wen Chen Yu-Jun Chang Lih-Ju Chen Cheng-Han Lee Chien-Chou Hsiao Jia-Yuh Chen Hsiao-Neng Chen |
| author_facet | Yu-Wen Chen Yu-Jun Chang Lih-Ju Chen Cheng-Han Lee Chien-Chou Hsiao Jia-Yuh Chen Hsiao-Neng Chen |
| author_sort | Yu-Wen Chen |
| collection | DOAJ |
| description | Metabolic bone disease (MBD) predominantly affects preterm infants, particularly very-low-birth-weight (VLBW) infants weighing <1500 g. However, there are limited reports on MBD and neurodevelopmental outcomes. This study aimed to analyze the risk factors for MBD and understand its impact on neurodevelopmental outcomes at 2 years of corrected age. Overall, 749 VLBW infants weighing <1350 g at birth were enrolled. Exclusion criteria were major congenital abnormalities, chromosomal abnormalities, and loss of follow-up on the Bayley Scales of Infant Development, Third Edition (BSID-III) test at 24 months of corrected age. Infants were retrospectively assessed by a trained case manager using the BSID-III test at 6, 12, and 24 months old. Infants were categorized as with or without MBD according to radiographic signs. Of those enrolled, 97 VLBW infants were diagnosed with MBD, compared to 362 VLBW infants without MBD. The proportion of infants that completed three follow-ups was 86%. At the assessment at 2 years of age, infants with MBD had lower and more significant differences in motor, language, and cognitive composites. MBD is associated with poor neurodevelopmental outcomes in cognitive, motor, and language composites for VLBW infants at 24 months of corrected age. |
| first_indexed | 2024-03-08T11:00:53Z |
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| id | doaj.art-2d04c022bb2a476989c93e530b348f62 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-08T11:00:53Z |
| publishDate | 2024-01-01 |
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| series | Children |
| spelling | doaj.art-2d04c022bb2a476989c93e530b348f622024-01-26T15:48:21ZengMDPI AGChildren2227-90672024-01-011117610.3390/children11010076Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of AgeYu-Wen Chen0Yu-Jun Chang1Lih-Ju Chen2Cheng-Han Lee3Chien-Chou Hsiao4Jia-Yuh Chen5Hsiao-Neng Chen6Department of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanBig Data Center, Changhua Christian Hospital, No. 135, Nanxiao Street, Changhua City 500209, TaiwanDepartment of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanDepartment of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanDepartment of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanDepartment of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanDepartment of Neonatology, Changhua Christian Children’s Hospital, No. 320, Xuguang Road, Changhua City 500010, TaiwanMetabolic bone disease (MBD) predominantly affects preterm infants, particularly very-low-birth-weight (VLBW) infants weighing <1500 g. However, there are limited reports on MBD and neurodevelopmental outcomes. This study aimed to analyze the risk factors for MBD and understand its impact on neurodevelopmental outcomes at 2 years of corrected age. Overall, 749 VLBW infants weighing <1350 g at birth were enrolled. Exclusion criteria were major congenital abnormalities, chromosomal abnormalities, and loss of follow-up on the Bayley Scales of Infant Development, Third Edition (BSID-III) test at 24 months of corrected age. Infants were retrospectively assessed by a trained case manager using the BSID-III test at 6, 12, and 24 months old. Infants were categorized as with or without MBD according to radiographic signs. Of those enrolled, 97 VLBW infants were diagnosed with MBD, compared to 362 VLBW infants without MBD. The proportion of infants that completed three follow-ups was 86%. At the assessment at 2 years of age, infants with MBD had lower and more significant differences in motor, language, and cognitive composites. MBD is associated with poor neurodevelopmental outcomes in cognitive, motor, and language composites for VLBW infants at 24 months of corrected age.https://www.mdpi.com/2227-9067/11/1/76metabolic bone diseaseneurodevelopmental outcomesvery-low-birth-weight infantsrisk factorsBayley Scales of Infant Development-III |
| spellingShingle | Yu-Wen Chen Yu-Jun Chang Lih-Ju Chen Cheng-Han Lee Chien-Chou Hsiao Jia-Yuh Chen Hsiao-Neng Chen Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age Children metabolic bone disease neurodevelopmental outcomes very-low-birth-weight infants risk factors Bayley Scales of Infant Development-III |
| title | Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age |
| title_full | Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age |
| title_fullStr | Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age |
| title_full_unstemmed | Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age |
| title_short | Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age |
| title_sort | neurodevelopment outcomes in very low birth weight infants with metabolic bone disease at 2 years of age |
| topic | metabolic bone disease neurodevelopmental outcomes very-low-birth-weight infants risk factors Bayley Scales of Infant Development-III |
| url | https://www.mdpi.com/2227-9067/11/1/76 |
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