NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4 (PAD4), the role of the NLRP3 inflammasome in...

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Bibliographic Details
Main Authors: Patrick Münzer, Roberto Negro, Shoichi Fukui, Lucas di Meglio, Karen Aymonnier, Long Chu, Deya Cherpokova, Sarah Gutch, Nicoletta Sorvillo, Lai Shi, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Clare M. Waterman, Hao Wu, Denisa D. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Neutrophils
NETs
NLRP3 inflammasome
MCC950
deep vein thrombosis
PAD4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.683803/full

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