Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila
It is well-known that the innate immune mechanisms in fish serve as the first line of defence against wide variety of pathogens. In most of the situations, innate responses get induced and enhanced after the pathogen invasion. It would be interesting to look into the inducibility of various innate i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tripoli University
2017-06-01
|
| Series: | Open Veterinary Journal |
| Subjects: | |
| Online Access: | http://www.openveterinaryjournal.com/2017/Volume%207%20No%202/OVJ-2017-02-025%20S.K.%20Priyadarshini%20et%20al.pdf |
| _version_ | 1831571503339012096 |
|---|---|
| author | S. Kalaivani Priyadarshini Parasuraman Aiya Subramani R. Dinakaran Michael |
| author_facet | S. Kalaivani Priyadarshini Parasuraman Aiya Subramani R. Dinakaran Michael |
| author_sort | S. Kalaivani Priyadarshini |
| collection | DOAJ |
| description | It is well-known that the innate immune mechanisms in fish serve as the first line of defence against wide variety of pathogens. In most of the situations, innate responses get induced and enhanced after the pathogen invasion. It would be interesting to look into the inducibility of various innate immune mechanisms and the level of enhancement after infection with the pathogen. Hence, in the present investigation, modulation of the innate immune responses in the striped snakehead murrel, Channa striata on experimental challenge with either live virulent or heat killed Aeromonas hydrophila at a dose of 1× 107 CFU mL-1 were measured. Most of the non-specific (both humoral and cellular) immune responses tested were substantially induced or enhanced in both the experimental groups in comparison with the unchallenged control group. Significant increase in the lysozyme, total peroxidase, antiprotease and respiratory burst activities were observed after the pathogen challenge. Thus, most of the innate non-specific immune responses are inducible though they are constitutive of fish immune system exhibiting a basal level of activity even in the absence of pathogen challenge. |
| first_indexed | 2024-12-17T13:09:57Z |
| format | Article |
| id | doaj.art-2d067a4dda65424a8b68e8a531817570 |
| institution | Directory Open Access Journal |
| issn | 2218-6050 2218-6050 |
| language | English |
| last_indexed | 2024-12-17T13:09:57Z |
| publishDate | 2017-06-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-2d067a4dda65424a8b68e8a5318175702022-12-21T21:47:08ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502017-06-0172157164http://dx.doi.org/10.4314/ovj.v7i2.13Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophilaS. Kalaivani Priyadarshini0Parasuraman Aiya Subramani1R. Dinakaran Michael2P.G. and Research Department of Zoology and Biotechnology, Lady Doak College, Madurai-625002, IndiaCentre for Fish Immunology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), VELS University, Chennai – 600117, IndiaCentre for Fish Immunology, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), VELS University, Chennai – 600117, IndiaIt is well-known that the innate immune mechanisms in fish serve as the first line of defence against wide variety of pathogens. In most of the situations, innate responses get induced and enhanced after the pathogen invasion. It would be interesting to look into the inducibility of various innate immune mechanisms and the level of enhancement after infection with the pathogen. Hence, in the present investigation, modulation of the innate immune responses in the striped snakehead murrel, Channa striata on experimental challenge with either live virulent or heat killed Aeromonas hydrophila at a dose of 1× 107 CFU mL-1 were measured. Most of the non-specific (both humoral and cellular) immune responses tested were substantially induced or enhanced in both the experimental groups in comparison with the unchallenged control group. Significant increase in the lysozyme, total peroxidase, antiprotease and respiratory burst activities were observed after the pathogen challenge. Thus, most of the innate non-specific immune responses are inducible though they are constitutive of fish immune system exhibiting a basal level of activity even in the absence of pathogen challenge.http://www.openveterinaryjournal.com/2017/Volume%207%20No%202/OVJ-2017-02-025%20S.K.%20Priyadarshini%20et%20al.pdfAeromonas hydrophilaExperimental challengeInnate immune responseStriped snakehead murrel |
| spellingShingle | S. Kalaivani Priyadarshini Parasuraman Aiya Subramani R. Dinakaran Michael Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila Open Veterinary Journal Aeromonas hydrophila Experimental challenge Innate immune response Striped snakehead murrel |
| title | Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila |
| title_full | Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila |
| title_fullStr | Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila |
| title_full_unstemmed | Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila |
| title_short | Modulation of the innate immune responses in the striped snakehead murrel, Channa striata upon experimental infection with live and heat killed Aeromonas hydrophila |
| title_sort | modulation of the innate immune responses in the striped snakehead murrel channa striata upon experimental infection with live and heat killed aeromonas hydrophila |
| topic | Aeromonas hydrophila Experimental challenge Innate immune response Striped snakehead murrel |
| url | http://www.openveterinaryjournal.com/2017/Volume%207%20No%202/OVJ-2017-02-025%20S.K.%20Priyadarshini%20et%20al.pdf |
| work_keys_str_mv | AT skalaivanipriyadarshini modulationoftheinnateimmuneresponsesinthestripedsnakeheadmurrelchannastriatauponexperimentalinfectionwithliveandheatkilledaeromonashydrophila AT parasuramanaiyasubramani modulationoftheinnateimmuneresponsesinthestripedsnakeheadmurrelchannastriatauponexperimentalinfectionwithliveandheatkilledaeromonashydrophila AT rdinakaranmichael modulationoftheinnateimmuneresponsesinthestripedsnakeheadmurrelchannastriatauponexperimentalinfectionwithliveandheatkilledaeromonashydrophila |