A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds

Context: Split thickness skin grafting (STSG) restores cutaneous cover over wounds thus protecting the underlying surface from contamination, fluid loss and stimulates healing. Autologous platelet rich plasma (PRP) provides a large number of platelets and high concentration of growth factors which p...

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Main Authors: Urbee Gupta, Anilkumar P Bellad, Rajesh S Powar, Chetan V Sultanpur
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Journal of the Scientific Society
Subjects:
Online Access:http://www.jscisociety.com/article.asp?issn=0974-5009;year=2024;volume=51;issue=1;spage=46;epage=51;aulast=Gupta
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author Urbee Gupta
Anilkumar P Bellad
Rajesh S Powar
Chetan V Sultanpur
author_facet Urbee Gupta
Anilkumar P Bellad
Rajesh S Powar
Chetan V Sultanpur
author_sort Urbee Gupta
collection DOAJ
description Context: Split thickness skin grafting (STSG) restores cutaneous cover over wounds thus protecting the underlying surface from contamination, fluid loss and stimulates healing. Autologous platelet rich plasma (PRP) provides a large number of platelets and high concentration of growth factors which promote overall uptake of STSG. Aims: The aim of this study was to assess the immediate, subsequent adhesion and final take of STSG with application of PRP over recipient site. Methods and Material: 1 year Randomised Control Trial where 80 wounds of various aetiologies were randomised into intervention group (n=40) which received PRP before placing STSG on recipient site and control group (n=40) in which the graft was fixed in place with sutures alone. Immediate graft adhesion and subsequent graft uptake were compared between the two groups and statistical analysis was done with: SPSS Version 20. Results: Irrespective of aetiology, and size, among a total of 80 wounds 87.5% grafts had adhered by 1st minute of application in the intervention group compared to nil in control group (p< 0.0001). Graft uptake was assessed on first three consecutive dressings. There was significantly better graft uptake in intervention group compared to control group [third dressing uptake (98.29%, 93%, p< 0.0001) respectively].Difference in seroma and haematoma formation were also compared between the two groups and found to be not significant. (p>0.05) Conclusions: Application of topical PRP facilitates STSG uptake. It decreases operative time by decreasing mobility of graft over the wound bed. Thus, use of PRP improves outcome of split thickness skin graft in wounds of various aetiologies and we recommend use of the same at recipient site of STSG. CTRI/2021/06/034401
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spelling doaj.art-2d06d2838bf7404682e5e37ae4679ae02024-03-25T12:58:35ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092024-01-01511465110.4103/jss.jss_333_22A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on woundsUrbee GuptaAnilkumar P BelladRajesh S PowarChetan V SultanpurContext: Split thickness skin grafting (STSG) restores cutaneous cover over wounds thus protecting the underlying surface from contamination, fluid loss and stimulates healing. Autologous platelet rich plasma (PRP) provides a large number of platelets and high concentration of growth factors which promote overall uptake of STSG. Aims: The aim of this study was to assess the immediate, subsequent adhesion and final take of STSG with application of PRP over recipient site. Methods and Material: 1 year Randomised Control Trial where 80 wounds of various aetiologies were randomised into intervention group (n=40) which received PRP before placing STSG on recipient site and control group (n=40) in which the graft was fixed in place with sutures alone. Immediate graft adhesion and subsequent graft uptake were compared between the two groups and statistical analysis was done with: SPSS Version 20. Results: Irrespective of aetiology, and size, among a total of 80 wounds 87.5% grafts had adhered by 1st minute of application in the intervention group compared to nil in control group (p< 0.0001). Graft uptake was assessed on first three consecutive dressings. There was significantly better graft uptake in intervention group compared to control group [third dressing uptake (98.29%, 93%, p< 0.0001) respectively].Difference in seroma and haematoma formation were also compared between the two groups and found to be not significant. (p>0.05) Conclusions: Application of topical PRP facilitates STSG uptake. It decreases operative time by decreasing mobility of graft over the wound bed. Thus, use of PRP improves outcome of split thickness skin graft in wounds of various aetiologies and we recommend use of the same at recipient site of STSG. CTRI/2021/06/034401http://www.jscisociety.com/article.asp?issn=0974-5009;year=2024;volume=51;issue=1;spage=46;epage=51;aulast=Guptaanchoringplatelet-rich plasmasplit-thickness skin graftssutures
spellingShingle Urbee Gupta
Anilkumar P Bellad
Rajesh S Powar
Chetan V Sultanpur
A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
Journal of the Scientific Society
anchoring
platelet-rich plasma
split-thickness skin grafts
sutures
title A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
title_full A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
title_fullStr A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
title_full_unstemmed A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
title_short A comparison of efficacy of autologous platelet-rich plasma and conventional sutures in anchoring split skin graft on wounds
title_sort comparison of efficacy of autologous platelet rich plasma and conventional sutures in anchoring split skin graft on wounds
topic anchoring
platelet-rich plasma
split-thickness skin grafts
sutures
url http://www.jscisociety.com/article.asp?issn=0974-5009;year=2024;volume=51;issue=1;spage=46;epage=51;aulast=Gupta
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