Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection
In this study, we use NEGF quantum transport simulations to study the fundamental detection limit of ultra-scaled Si nanowire FET (NWT) biosensors. A N-doped NWT is found to be more sensitive for negatively charged analytes as explained by the nature of the detection mechanism. Our results predict t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/12/5405 |
| _version_ | 1797592694165340160 |
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| author | Aryan Afzalian Denis Flandre |
| author_facet | Aryan Afzalian Denis Flandre |
| author_sort | Aryan Afzalian |
| collection | DOAJ |
| description | In this study, we use NEGF quantum transport simulations to study the fundamental detection limit of ultra-scaled Si nanowire FET (NWT) biosensors. A N-doped NWT is found to be more sensitive for negatively charged analytes as explained by the nature of the detection mechanism. Our results predict threshold voltage shifts due to a single-charge analyte of tens to hundreds of mV in air or low-ionic solutions. However, with typical ionic solutions and SAM conditions, the sensitivity rapidly drops to the mV/q range. Our results are then extended to the detection of a single 20-base-long DNA molecule in solution. The impact of front- and/or back-gate biasing on the sensitivity and limit of detection is studied and a signal-to-noise ratio of 10 is predicted. Opportunities and challenges to reach down to single-analyte detection in such systems are also discussed, including the ionic and oxide-solution interface-charge screening and ways to recover unscreened sensitivities. |
| first_indexed | 2024-03-11T01:57:44Z |
| format | Article |
| id | doaj.art-2d08a43c5211418fa3aedb4499dee570 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T01:57:44Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-2d08a43c5211418fa3aedb4499dee5702023-11-18T12:30:32ZengMDPI AGSensors1424-82202023-06-012312540510.3390/s23125405Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule DetectionAryan Afzalian0Denis Flandre1Imec, 3001 Leuven, BelgiumUCLouvain, 1348 Louvain-la-Neuve, BelgiumIn this study, we use NEGF quantum transport simulations to study the fundamental detection limit of ultra-scaled Si nanowire FET (NWT) biosensors. A N-doped NWT is found to be more sensitive for negatively charged analytes as explained by the nature of the detection mechanism. Our results predict threshold voltage shifts due to a single-charge analyte of tens to hundreds of mV in air or low-ionic solutions. However, with typical ionic solutions and SAM conditions, the sensitivity rapidly drops to the mV/q range. Our results are then extended to the detection of a single 20-base-long DNA molecule in solution. The impact of front- and/or back-gate biasing on the sensitivity and limit of detection is studied and a signal-to-noise ratio of 10 is predicted. Opportunities and challenges to reach down to single-analyte detection in such systems are also discussed, including the ionic and oxide-solution interface-charge screening and ways to recover unscreened sensitivities.https://www.mdpi.com/1424-8220/23/12/5405biomoleculeDNAionsMOSFETsnanotechnologyquantum wires |
| spellingShingle | Aryan Afzalian Denis Flandre Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection Sensors biomolecule DNA ions MOSFETs nanotechnology quantum wires |
| title | Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection |
| title_full | Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection |
| title_fullStr | Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection |
| title_full_unstemmed | Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection |
| title_short | Ultra-Scaled Si Nanowire Biosensors for Single DNA Molecule Detection |
| title_sort | ultra scaled si nanowire biosensors for single dna molecule detection |
| topic | biomolecule DNA ions MOSFETs nanotechnology quantum wires |
| url | https://www.mdpi.com/1424-8220/23/12/5405 |
| work_keys_str_mv | AT aryanafzalian ultrascaledsinanowirebiosensorsforsinglednamoleculedetection AT denisflandre ultrascaledsinanowirebiosensorsforsinglednamoleculedetection |