Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene
Background: In this last decade, a huge increase in African anthropophilic strains causing tinea capitis has been observed in Europe. The Belgian National Reference Center for Mycosis (NRC) conducted a surveillance study on tinea capitis in 2018 to learn the profile of circulating dermatophytes. Met...
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MDPI AG
2020-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/6/4/195 |
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| author | Rosalie Sacheli Saadia Harag Florence Dehavay Séverine Evrard Danielle Rousseaux Akole Adjetey Laurence Seidel Kim Laffineur Katrien Lagrou Marie-Pierre Hayette |
| author_facet | Rosalie Sacheli Saadia Harag Florence Dehavay Séverine Evrard Danielle Rousseaux Akole Adjetey Laurence Seidel Kim Laffineur Katrien Lagrou Marie-Pierre Hayette |
| author_sort | Rosalie Sacheli |
| collection | DOAJ |
| description | Background: In this last decade, a huge increase in African anthropophilic strains causing tinea capitis has been observed in Europe. The Belgian National Reference Center for Mycosis (NRC) conducted a surveillance study on tinea capitis in 2018 to learn the profile of circulating dermatophytes. Methods: Belgian laboratories were invited to send all dermatophyte strains isolated from the scalp with epidemiological information. Strain identification was confirmed by ITS (Internal Transcribed Spacer) sequencing. Mutation in the squalene epoxidase (SQLE) gene was screened by PCR. Results: The main population affected by tinea capitis was children from 5–9 years. Males were more affected than females. The majority of the strains were collected in the Brussels area followed by the Liege area. Among known ethnic origins, African people were more affected by tinea capitis than European people. The major aetiological agent was <i>Microsporum audouinii</i>, followed by <i>Trichophyton soudanense</i>. One strain of <i>Trichophyton mentagrophytes</i> has been characterized to have a mutation on the squalene epoxidase gene and to be resistant to terbinafine. Conclusions: African anthropophilic dermatophytes are mainly responsible for tinea capitis in Belgium. People of African origin are most affected by tinea capitis. The monitoring of terbinafine resistance among dermatophytes seems necessary as we have demonstrated the emergence of resistance in <i>T. mentagrophytes</i>. |
| first_indexed | 2024-03-10T15:58:36Z |
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| last_indexed | 2024-03-10T15:58:36Z |
| publishDate | 2020-09-01 |
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| series | Journal of Fungi |
| spelling | doaj.art-2d096d556a3647289cd1c4147b3741042023-11-20T15:27:38ZengMDPI AGJournal of Fungi2309-608X2020-09-016419510.3390/jof6040195Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE GeneRosalie Sacheli0Saadia Harag1Florence Dehavay2Séverine Evrard3Danielle Rousseaux4Akole Adjetey5Laurence Seidel6Kim Laffineur7Katrien Lagrou8Marie-Pierre Hayette9Department of Clinical Microbiology, Belgian National Reference Center for Mycoses, University Hospital of Liege, 4000 Liège, BelgiumDepartment of Dermatology, University Hospital St Pierre Brussels, 1000 Brussels, BelgiumDepartment of Dermatology, University Hospital St Pierre Brussels, 1000 Brussels, BelgiumDepartment of Clinical Microbiology, CHR, Citadelle, Regional Hospital of Liege, 4000 Liège, BelgiumDepartment of Clinical Microbiology, CHC Group, Montlegia Hospital, 4000 Liege, BelgiumDepartment of Clinical Microbiology, Belgian National Reference Center for Mycoses, University Hospital of Liege, 4000 Liège, BelgiumDepartment of Biostatistics, University Hospital of Liege, 4000 Liège, BelgiumDepartment of Microbiology, St Luc Hospital Bouge, 5004 Bouge, BelgiumLaboratory of Clinical Bacteriology and Mycology, Belgian National Reference Center, University Hospital of Leuven, 3000 Leuven, BelgiumDepartment of Clinical Microbiology, Belgian National Reference Center for Mycoses, University Hospital of Liege, 4000 Liège, BelgiumBackground: In this last decade, a huge increase in African anthropophilic strains causing tinea capitis has been observed in Europe. The Belgian National Reference Center for Mycosis (NRC) conducted a surveillance study on tinea capitis in 2018 to learn the profile of circulating dermatophytes. Methods: Belgian laboratories were invited to send all dermatophyte strains isolated from the scalp with epidemiological information. Strain identification was confirmed by ITS (Internal Transcribed Spacer) sequencing. Mutation in the squalene epoxidase (SQLE) gene was screened by PCR. Results: The main population affected by tinea capitis was children from 5–9 years. Males were more affected than females. The majority of the strains were collected in the Brussels area followed by the Liege area. Among known ethnic origins, African people were more affected by tinea capitis than European people. The major aetiological agent was <i>Microsporum audouinii</i>, followed by <i>Trichophyton soudanense</i>. One strain of <i>Trichophyton mentagrophytes</i> has been characterized to have a mutation on the squalene epoxidase gene and to be resistant to terbinafine. Conclusions: African anthropophilic dermatophytes are mainly responsible for tinea capitis in Belgium. People of African origin are most affected by tinea capitis. The monitoring of terbinafine resistance among dermatophytes seems necessary as we have demonstrated the emergence of resistance in <i>T. mentagrophytes</i>.https://www.mdpi.com/2309-608X/6/4/195tinea capitisdermatophytesBelgiumresistanceterbinafineprevalence |
| spellingShingle | Rosalie Sacheli Saadia Harag Florence Dehavay Séverine Evrard Danielle Rousseaux Akole Adjetey Laurence Seidel Kim Laffineur Katrien Lagrou Marie-Pierre Hayette Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene Journal of Fungi tinea capitis dermatophytes Belgium resistance terbinafine prevalence |
| title | Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene |
| title_full | Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene |
| title_fullStr | Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene |
| title_full_unstemmed | Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene |
| title_short | Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant <i>T. mentagrophytes</i> with a Mutation on SQLE Gene |
| title_sort | belgian national survey on tinea capitis epidemiological considerations and highlight of terbinafine resistant i t mentagrophytes i with a mutation on sqle gene |
| topic | tinea capitis dermatophytes Belgium resistance terbinafine prevalence |
| url | https://www.mdpi.com/2309-608X/6/4/195 |
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