Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients
Purpose: The study was performed to analyze the prevalence of the conjunctival ultraviolet autofluorescence (CUVAF) area in keratoconic eyes and changes caused by UVA-irradiation as a component of accelerated corneal cross-linking (aCXL). Methods: The study group involved 20 keratoconic patients sub...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2693 |
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| author | Arleta Waszczykowska Krzysztof Bartosiewicz Michał Podgórski Ewa Zmysłowska-Polakowska Piotr Jurowski |
| author_facet | Arleta Waszczykowska Krzysztof Bartosiewicz Michał Podgórski Ewa Zmysłowska-Polakowska Piotr Jurowski |
| author_sort | Arleta Waszczykowska |
| collection | DOAJ |
| description | Purpose: The study was performed to analyze the prevalence of the conjunctival ultraviolet autofluorescence (CUVAF) area in keratoconic eyes and changes caused by UVA-irradiation as a component of accelerated corneal cross-linking (aCXL). Methods: The study group involved 20 keratoconic patients subjected to aCXL surgery in one eye. The comparative group consisted of 111 age- and sex-matched patients with healthy corneas. The images of the anterior segment in both patient groups were taken using a Coroneo camera. In the study group the photos were taken before and immediately after the surgery, and 7 and 30 days following the procedure. Results: Nasal and temporal autofluorescence area (AN+T) were significantly smaller in a keratoconic patients group compared to control group (<i>p</i> = 0.0001). Patients with the third stage of keratoconus had significantly higher AN+T (<i>p</i> = 0.0277) compared with individuals with lower stage keratoconus. No statistically significant CUVAF changes were observed after the aCXL procedure. In keratoconic patients with primary CUVAF undergoing aCXL, a temporary fast enlargement of the autofluorescence area was observed. Conclusions: The eyes undergoing the aCXL procedure showed no difference in the size of the CUVAF area but such patients should be in strict follow-up in order to reveal UV-related ocular surface diseases. |
| first_indexed | 2024-03-10T17:07:39Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T17:07:39Z |
| publishDate | 2020-08-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2d09766a212346b7a9511355e478d5872023-11-20T10:45:26ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0199269310.3390/jcm9092693Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic PatientsArleta Waszczykowska0Krzysztof Bartosiewicz1Michał Podgórski2Ewa Zmysłowska-Polakowska3Piotr Jurowski4Department of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandDepartment of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandDepartment of Diagnostic Imaging, Polish Mother’s Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, PolandDepartment of Endodontics, Medical University of Lodz, Pomorska 251, 92-216 Łódź, PolandDepartment of Ophthalmology and Vision Rehabilitation, 2nd Chair of Eye Diseases, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandPurpose: The study was performed to analyze the prevalence of the conjunctival ultraviolet autofluorescence (CUVAF) area in keratoconic eyes and changes caused by UVA-irradiation as a component of accelerated corneal cross-linking (aCXL). Methods: The study group involved 20 keratoconic patients subjected to aCXL surgery in one eye. The comparative group consisted of 111 age- and sex-matched patients with healthy corneas. The images of the anterior segment in both patient groups were taken using a Coroneo camera. In the study group the photos were taken before and immediately after the surgery, and 7 and 30 days following the procedure. Results: Nasal and temporal autofluorescence area (AN+T) were significantly smaller in a keratoconic patients group compared to control group (<i>p</i> = 0.0001). Patients with the third stage of keratoconus had significantly higher AN+T (<i>p</i> = 0.0277) compared with individuals with lower stage keratoconus. No statistically significant CUVAF changes were observed after the aCXL procedure. In keratoconic patients with primary CUVAF undergoing aCXL, a temporary fast enlargement of the autofluorescence area was observed. Conclusions: The eyes undergoing the aCXL procedure showed no difference in the size of the CUVAF area but such patients should be in strict follow-up in order to reveal UV-related ocular surface diseases.https://www.mdpi.com/2077-0383/9/9/2693conjunctival ultraviolet autofluorescenceCUVAFkeratoconuscorneal cross-linkingaCXLultraviolet A |
| spellingShingle | Arleta Waszczykowska Krzysztof Bartosiewicz Michał Podgórski Ewa Zmysłowska-Polakowska Piotr Jurowski Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients Journal of Clinical Medicine conjunctival ultraviolet autofluorescence CUVAF keratoconus corneal cross-linking aCXL ultraviolet A |
| title | Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients |
| title_full | Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients |
| title_fullStr | Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients |
| title_full_unstemmed | Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients |
| title_short | Conjunctival Ultraviolet Autofluorescence as a Measure of Riboflavin and Ultraviolet and Accelerated Cross-Linking Exposure in Keratoconic Patients |
| title_sort | conjunctival ultraviolet autofluorescence as a measure of riboflavin and ultraviolet and accelerated cross linking exposure in keratoconic patients |
| topic | conjunctival ultraviolet autofluorescence CUVAF keratoconus corneal cross-linking aCXL ultraviolet A |
| url | https://www.mdpi.com/2077-0383/9/9/2693 |
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