Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats
Introduction: Essential oils are considered a potential alternative to synthetic drugs in the management of diseases such as peptic ulcer (PU) and ulcerative colitis (UC). This study is concerned with comparing the therapeutic effects of Cuminum cyminum L, Carum carvi L, and Thymus vulgaris L. essen...
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Shahrekord University of Medical Sciences
2022-07-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/jhp-11-389.pdf |
| _version_ | 1811342286126055424 |
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| author | Nehad Naem Hamed Shosha Nouran M. Fahmy Abdel Nasser B. Singab Radwa Wahid Mohamed |
| author_facet | Nehad Naem Hamed Shosha Nouran M. Fahmy Abdel Nasser B. Singab Radwa Wahid Mohamed |
| author_sort | Nehad Naem Hamed Shosha |
| collection | DOAJ |
| description | Introduction: Essential oils are considered a potential alternative to synthetic drugs in the management of diseases such as peptic ulcer (PU) and ulcerative colitis (UC). This study is concerned with comparing the therapeutic effects of Cuminum cyminum L, Carum carvi L, and Thymus vulgaris L. essential oils on PU and UC models induced by ethanol. Methods: Rats were divided into 10 groups; control groups were treated with saline and experimental groups with 500 mg/kg body weight of C. cyminum, C. carvi, or T. vulgaris essential oil. Curative effects were determined by measuring tissue oxidative markers, such as reduced glutathione (GSH), malondialdehyde (MDA), and myeloperoxidase (MPO), as well as the inflammatory marker prostaglandin E2 (PGE2), stomach pepsin (PEP), and colon alkaline phosphatase (ALP). Biochemical and histological examinations were done on stomach and colon tissues. Results: The current study proved the anti-ulcer effects of C. cyminum, C. carvi, and T. vulgaris essential oils. They improved the oxidative and inflammatory markers in both stomach and colon tissues and modulated stomach PEP and colon ALP activities. T. vulgaris essential oil modulated GSH and MDA levels resulting in a significant elevation in GSH levels by 120.43% and 99.46% and a significant reduction in MDA levels by 20.05% and 24.1% in PU and UC models, respectively. C. carvi essential oil was the most effective in restoring PGE2 by 71.51% compared to UC group. Results were confirmed by the morphological and histopathological changes. Conclusion: C. cyminum, C. carvi, or T. vulgaris essential oils might be used in the management of acute PU and UC. |
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| language | English |
| last_indexed | 2024-04-13T19:08:55Z |
| publishDate | 2022-07-01 |
| publisher | Shahrekord University of Medical Sciences |
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| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-2d0a52cd462f4a5a84a96b9e66333c3c2022-12-22T02:33:54ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042022-07-0111338940010.34172/jhp.2022.45jhp-42354Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in ratsNehad Naem Hamed Shosha0Nouran M. Fahmy1Abdel Nasser B. Singab2Radwa Wahid Mohamed3Department of Biochemistry and Nutrition, Faculty of women for Arts Science and Education, Ain Shams University, Cairo, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, EgyptDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, EgyptDepartment of Biochemistry and Nutrition, Faculty of women for Arts Science and Education, Ain Shams University, Cairo, EgyptIntroduction: Essential oils are considered a potential alternative to synthetic drugs in the management of diseases such as peptic ulcer (PU) and ulcerative colitis (UC). This study is concerned with comparing the therapeutic effects of Cuminum cyminum L, Carum carvi L, and Thymus vulgaris L. essential oils on PU and UC models induced by ethanol. Methods: Rats were divided into 10 groups; control groups were treated with saline and experimental groups with 500 mg/kg body weight of C. cyminum, C. carvi, or T. vulgaris essential oil. Curative effects were determined by measuring tissue oxidative markers, such as reduced glutathione (GSH), malondialdehyde (MDA), and myeloperoxidase (MPO), as well as the inflammatory marker prostaglandin E2 (PGE2), stomach pepsin (PEP), and colon alkaline phosphatase (ALP). Biochemical and histological examinations were done on stomach and colon tissues. Results: The current study proved the anti-ulcer effects of C. cyminum, C. carvi, and T. vulgaris essential oils. They improved the oxidative and inflammatory markers in both stomach and colon tissues and modulated stomach PEP and colon ALP activities. T. vulgaris essential oil modulated GSH and MDA levels resulting in a significant elevation in GSH levels by 120.43% and 99.46% and a significant reduction in MDA levels by 20.05% and 24.1% in PU and UC models, respectively. C. carvi essential oil was the most effective in restoring PGE2 by 71.51% compared to UC group. Results were confirmed by the morphological and histopathological changes. Conclusion: C. cyminum, C. carvi, or T. vulgaris essential oils might be used in the management of acute PU and UC.http://herbmedpharmacol.com/PDF/jhp-11-389.pdfinjuriesetiologycomplicationsdrug effectsadverse effectstherapeutic use |
| spellingShingle | Nehad Naem Hamed Shosha Nouran M. Fahmy Abdel Nasser B. Singab Radwa Wahid Mohamed Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats Journal of HerbMed Pharmacology injuries etiology complications drug effects adverse effects therapeutic use |
| title | Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats |
| title_full | Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats |
| title_fullStr | Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats |
| title_full_unstemmed | Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats |
| title_short | Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats |
| title_sort | anti ulcer effects of cumin cuminum cyminum l thyme thymus vulgaris l and caraway carum carvi l essential oils on peptic ulcer and ulcerative colitis models in rats |
| topic | injuries etiology complications drug effects adverse effects therapeutic use |
| url | http://herbmedpharmacol.com/PDF/jhp-11-389.pdf |
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