Changes within the P681 residue of spike dictate cell fusion and syncytia formation of Delta and Omicron variants of SARS-CoV-2 with no effects on neutralization or infectivity

Changes within the P681 residue of spike dictate cell fusion and syncytia formation of Delta and Omicron variants of SARS-CoV-2 with no effects on neutralization or infectivity

The rapid spread and dominance of the Omicron SARS-CoV-2 lineages have posed severe health challenges worldwide. While extensive research on the role of the Receptor Binding Domain (RBD) in promoting viral infectivity and vaccine sensitivity has been well documented, the functional significance of t...

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Bibliographic Details
Main Authors: Alona Kuzmina, Dina Korovin, Ido Cohen lass, Nofar Atari, Aner Ottolenghi, Pan Hu, Michal Mandelboim, Benyamin Rosental, Elli Rosenberg, Felipe Diaz-Griffero, Ran Taube
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
SARS-CoV-2
Spike
Fusion
Syncytia
Pfizer-BTN162b2
Neutralizing antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023039579

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