Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia
BackgroundMany studies reported that copper, zinc and magnesium play important roles in the pathogenesis and development of neonatal hyperbilirubinemia. Exchange transfusion and intensive phototherapy are known two modalities of therapy for severe neonatal hyper bilirubinemia, but the effect of them...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-02-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | http://ijp.mums.ac.ir/article_8213_0ab867686078923f9e6e136a43fb62ed.pdf |
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| author | Abdel-Azeem El-Mazary Reem Abdel Aziz Madiha Sayed Ramadan Mahmoud Ahmed Saedii |
| author_facet | Abdel-Azeem El-Mazary Reem Abdel Aziz Madiha Sayed Ramadan Mahmoud Ahmed Saedii |
| author_sort | Abdel-Azeem El-Mazary |
| collection | DOAJ |
| description | BackgroundMany studies reported that copper, zinc and magnesium play important roles in the pathogenesis and development of neonatal hyperbilirubinemia. Exchange transfusion and intensive phototherapy are known two modalities of therapy for severe neonatal hyper bilirubinemia, but the effect of them on those trace elements is unknown.Materials and MethodsCopper, Zinc and Magnesium serum levels were measured before and after treatment with intensive phototherapy and exchange transfusion in full term neonates with indirect hyperbilirubinemia admitted to neonatal intensive care unit (NICU) of Minia and Sohag University hospitals, Egypt, during 2014-2016 and comparison with normal healthy neonates was done.ResultsThere were significant higher copper and magnesium and lower zinc serum levels in neonates with indirect hyperbilirubinemia than controls before and after intensive phototherapy. These levels were significantly changed after exchange transfusion to be comparable with controls. Significant positive correlations between the total bilirubin levels and hemoglobin, copper, and magnesium serum levels and significant negative correlations with serum zinc levels were present. There were no significant correlations between maternal and neonatal copper, zinc or magnesium serum levels.ConclusionNeonates with indirect hyperbilirubinemia had significant higher copper and magnesium and lower zinc serum levels than healthy neonates which were not related to their maternal serum levels. Intensive phototherapy had no effect on their levels while exchange transfusion changed these levels to be comparable with that of normal healthy neonates. |
| first_indexed | 2024-04-11T20:56:17Z |
| format | Article |
| id | doaj.art-2d0bb58bdb0f45c69730e97401722791 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-04-11T20:56:17Z |
| publishDate | 2017-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-2d0bb58bdb0f45c69730e974017227912022-12-22T04:03:40ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552017-02-01524371438310.22038/ijp.2017.20566.17168213Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect HyperbilirubinemiaAbdel-Azeem El-Mazary0Reem Abdel Aziz1Madiha Sayed2Ramadan Mahmoud3Ahmed Saedii4Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.Department of Pediatrics, Faculty of Medicine, Sohag University, Egypt.Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.Department of Pediatrics, Faculty of Medicine, Sohag University, Egypt.Department of Clinical-Pathology, Faculty of Medicine, Minia University, Egypt.BackgroundMany studies reported that copper, zinc and magnesium play important roles in the pathogenesis and development of neonatal hyperbilirubinemia. Exchange transfusion and intensive phototherapy are known two modalities of therapy for severe neonatal hyper bilirubinemia, but the effect of them on those trace elements is unknown.Materials and MethodsCopper, Zinc and Magnesium serum levels were measured before and after treatment with intensive phototherapy and exchange transfusion in full term neonates with indirect hyperbilirubinemia admitted to neonatal intensive care unit (NICU) of Minia and Sohag University hospitals, Egypt, during 2014-2016 and comparison with normal healthy neonates was done.ResultsThere were significant higher copper and magnesium and lower zinc serum levels in neonates with indirect hyperbilirubinemia than controls before and after intensive phototherapy. These levels were significantly changed after exchange transfusion to be comparable with controls. Significant positive correlations between the total bilirubin levels and hemoglobin, copper, and magnesium serum levels and significant negative correlations with serum zinc levels were present. There were no significant correlations between maternal and neonatal copper, zinc or magnesium serum levels.ConclusionNeonates with indirect hyperbilirubinemia had significant higher copper and magnesium and lower zinc serum levels than healthy neonates which were not related to their maternal serum levels. Intensive phototherapy had no effect on their levels while exchange transfusion changed these levels to be comparable with that of normal healthy neonates.http://ijp.mums.ac.ir/article_8213_0ab867686078923f9e6e136a43fb62ed.pdfCopperHyperbilirubinemiaMagnesiumNeonatesPhototherapyZinc |
| spellingShingle | Abdel-Azeem El-Mazary Reem Abdel Aziz Madiha Sayed Ramadan Mahmoud Ahmed Saedii Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia International Journal of Pediatrics Copper Hyperbilirubinemia Magnesium Neonates Phototherapy Zinc |
| title | Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia |
| title_full | Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia |
| title_fullStr | Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia |
| title_full_unstemmed | Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia |
| title_short | Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia |
| title_sort | effect of intensive phototherapy and exchange transfusion on copper zinc and magnesium serum levels in neonates with indirect hyperbilirubinemia |
| topic | Copper Hyperbilirubinemia Magnesium Neonates Phototherapy Zinc |
| url | http://ijp.mums.ac.ir/article_8213_0ab867686078923f9e6e136a43fb62ed.pdf |
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