Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study
Trust propensity (TP) relies more on social than economic rationality to transform the perceived probability of betrayal into positive reciprocity expectations in older adults with normal cognition. While deficits in social rationality have been observed in older adults with mild cognitive impairmen...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924001009 |
| _version_ | 1797203082139926528 |
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| author | Yiqi Chen Hao He Yiyang Ding Wuhai Tao Qing Guan Frank Krueger |
| author_facet | Yiqi Chen Hao He Yiyang Ding Wuhai Tao Qing Guan Frank Krueger |
| author_sort | Yiqi Chen |
| collection | DOAJ |
| description | Trust propensity (TP) relies more on social than economic rationality to transform the perceived probability of betrayal into positive reciprocity expectations in older adults with normal cognition. While deficits in social rationality have been observed in older adults with mild cognitive impairment (MCI), there is limited research on TP and its associated resting-state functional connectivity (RSFC) mechanisms in this population. To measure TP and related psychological functions (affect, motivation, executive cognition, and social cognition), MCI (n = 42) and normal healthy control (NHC, n = 115) groups completed a one-shot trust game and additional assessments of related psychological functions. RSFC associated with TP was analyzed using connectome-based predictive modeling (CPM) and lesion simulations. Our behavioral results showed that the MCI group trusted less (i.e., had lower TP) than the NHC group, with lower TP associated with higher sensitivity to the probability of betrayal in the MCI group. In the MCI group, only negative CPM models (RSFC negatively correlated with TP) significantly predicted TP, with a high salience network (SN) contribution. In contrast, in the NHC group, positive CPM models (RSFC positively correlated with TP) significantly predicted TP, with a high contribution from the default mode network (DMN). In addition, the total network strength of the NHC-specific positive network was lower in the MCI group than in the NHC group. Our findings demonstrated a decrease in TP in the MCI group compared to the NHC group, which is associated with deficits in social rationality (social cognition, associated with DMN) and increased sensitivity to betrayal (affect, associated with SN) in a trust dilemma. In conclusion, our study contributes to understanding MCI-related alterations in trust and their underlying neural mechanisms. |
| first_indexed | 2024-04-24T08:13:40Z |
| format | Article |
| id | doaj.art-2d0cccb05c6c4e1aa648530021baf9c7 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-24T08:13:40Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-2d0cccb05c6c4e1aa648530021baf9c72024-04-17T04:48:36ZengElsevierNeuroImage1095-95722024-04-01292120605Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging studyYiqi Chen0Hao He1Yiyang Ding2Wuhai Tao3Qing Guan4Frank Krueger5School of Psychology, Shenzhen University, Shenzhen 518060, China; Department of Psychology, University of Mannheim, Mannheim 68131, GermanySchool of Psychology, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, ChinaSchool of Psychology, Shenzhen University, Shenzhen 518060, ChinaSchool of Psychology, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China; Co-corresponding authors at: School of Psychology, Shenzhen University, Nanhai Ave 3688, Nanshan District, Shenzhen City, Guangdong Province, Shenzhen, China.School of Psychology, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China; Co-corresponding authors at: School of Psychology, Shenzhen University, Nanhai Ave 3688, Nanshan District, Shenzhen City, Guangdong Province, Shenzhen, China.Department of Psychology, University of Mannheim, Mannheim 68131, Germany; School of Systems Biology, George Mason University, Fair, VA, USATrust propensity (TP) relies more on social than economic rationality to transform the perceived probability of betrayal into positive reciprocity expectations in older adults with normal cognition. While deficits in social rationality have been observed in older adults with mild cognitive impairment (MCI), there is limited research on TP and its associated resting-state functional connectivity (RSFC) mechanisms in this population. To measure TP and related psychological functions (affect, motivation, executive cognition, and social cognition), MCI (n = 42) and normal healthy control (NHC, n = 115) groups completed a one-shot trust game and additional assessments of related psychological functions. RSFC associated with TP was analyzed using connectome-based predictive modeling (CPM) and lesion simulations. Our behavioral results showed that the MCI group trusted less (i.e., had lower TP) than the NHC group, with lower TP associated with higher sensitivity to the probability of betrayal in the MCI group. In the MCI group, only negative CPM models (RSFC negatively correlated with TP) significantly predicted TP, with a high salience network (SN) contribution. In contrast, in the NHC group, positive CPM models (RSFC positively correlated with TP) significantly predicted TP, with a high contribution from the default mode network (DMN). In addition, the total network strength of the NHC-specific positive network was lower in the MCI group than in the NHC group. Our findings demonstrated a decrease in TP in the MCI group compared to the NHC group, which is associated with deficits in social rationality (social cognition, associated with DMN) and increased sensitivity to betrayal (affect, associated with SN) in a trust dilemma. In conclusion, our study contributes to understanding MCI-related alterations in trust and their underlying neural mechanisms.http://www.sciencedirect.com/science/article/pii/S1053811924001009Mild cognitive impairmentTrustIntrinsic functional connectivityNeuroeconomicsSocial dilemmas |
| spellingShingle | Yiqi Chen Hao He Yiyang Ding Wuhai Tao Qing Guan Frank Krueger Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study NeuroImage Mild cognitive impairment Trust Intrinsic functional connectivity Neuroeconomics Social dilemmas |
| title | Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study |
| title_full | Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study |
| title_fullStr | Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study |
| title_full_unstemmed | Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study |
| title_short | Connectome-based prediction of decreased trust propensity in older adults with mild cognitive impairment: A resting-state functional magnetic resonance imaging study |
| title_sort | connectome based prediction of decreased trust propensity in older adults with mild cognitive impairment a resting state functional magnetic resonance imaging study |
| topic | Mild cognitive impairment Trust Intrinsic functional connectivity Neuroeconomics Social dilemmas |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924001009 |
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