Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors. HA is initially synthesized as high molecular-weight (HMW) polymers, whi...

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Bibliographic Details
Main Authors: Muhan Liu, Cornelia Tolg, Eva Turley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
hyaluronan
hyaluronan receptors
tumor microenvironment
cancer resistance
tumor initiation
CD44
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00947/full

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